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Data from Guangzhou Medical University Advance Knowledge in Cancer Gene Therapy (Identification of potential pathways involved in the induction of...

July 24, 2014



Data from Guangzhou Medical University Advance Knowledge in Cancer Gene Therapy (Identification of potential pathways involved in the induction of cell cycle arrest and apoptosis by a new 4-arylidene curcumin analogue T63 in lung cancer cells: ...)

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- A new study on Biotechnology is now available. According to news reporting out of Guangzhou, People's Republic of China, by NewsRx editors, research stated, "Curcumin (diferuloylmethane) is a polyphenol natural product of the plant Curcuma longa, and has a diversity of antitumor activities. However, the clinical application of curcumin remains limited due to its poor pharmacokinetic characteristics."

Our news journalists obtained a quote from the research from Guangzhou Medical University, "It is therefore critical to develop structural analogues of curcumin with increasing anticancer activity. T63, a new 4-arylidene curcumin analogue, was synthesized in our previous studies and exhibited higher in vitro and in vivo anti-tumor activities compared to curcumin. However, the precise molecular mechanism of its anti-tumor effects has not been well elucidated. Using a two-dimensional gel electrophoresis (2-DE)-based proteomic approach, we identified 66 differentially expressed proteins. Similarly to curcumin, T63 showed a diverse range of molecular targets. We proposed that induction of ROS generation and mitochondrial dysfunction, inhibition of proteasome, HSP90, and 14-3-3 proteins play important roles in T63-induced cell cycle arrest and apoptosis."

According to the news editors, the research concluded: "These data indicate that the novel curcumin analogue T63 is a potent anti-tumor agent, which can induce cell cycle arrest and apoptosis, and also provided valuable resources for further study of the anti-tumor effects and molecular mechanisms of T63."

For more information on this research see: Identification of potential pathways involved in the induction of cell cycle arrest and apoptosis by a new 4-arylidene curcumin analogue T63 in lung cancer cells: a comparative proteomic analysis. Molecular Biosystems, 2014;10(6):1320-31. (Royal Society of Chemistry - www.rsc.org/; Molecular Biosystems - pubs.rsc.org/en/journals/journalissues/mb)

Our news journalists report that additional information may be obtained by contacting H. Liu, Affiliated Cancer Hospital and Cancer Research Institute, Guangzhou Medical University, Guangzhou 510095, People's Republic of China. Additional authors for this research include Y.Z. Liu, F. Zhang, H.S. Wang, G. Zhang, B.H. Zhou, Y.L. Zuo, S.H. Cai, X.Z. Bu and J. Du (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Alkanes, Curcumin, Oncology, Guangzhou, Catechols, Proteomics, Lung Cancer, Hydrocarbons, Lung Neoplasms, Diarylheptanoids, Organic Chemicals, Cancer Gene Therapy, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Gene Therapy Weekly


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