Studies from University of Cambridge Further Understanding of Chemical Physics (Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization)
By a News Reporter-Staff News Editor at Physics Week -- New research on Chemical Physics is the subject of a report. According to news reporting from Cambridge, United Kingdom, by VerticalNews journalists, research stated, "The formation of nanoscale protein filaments from soluble precursor molecules through nucleated polymerization is a common form of supra-molecular assembly phenomenon. This process underlies the generation of a range of both functional and pathological structures in nature."
The news correspondents obtained a quote from the research from the University of Cambridge, "Filament breakage has emerged as a key process controlling the kinetics of the growth reaction since it increases the number of filament ends in the system that can act as growth sites. In order to ensure microscopic reversibility, however, the inverse process of fragmentation, end-to-end annealing of filaments, is a necessary component of a consistent description of such systems. Here, we combine Smoluchowski kinetics with nucleated polymerization models to generate a master equation description of protein fibrillization, where filamentous structures can undergo end-to-end association, in addition to elongation, fragmentation, and nucleation processes. We obtain self-consistent closed-form expressions for the growth kinetics and discuss the key physics that emerges from considering filament fusion relative to current fragmentation only models."
According to the news reporters, the research concluded: "Furthermore, we study the key time scales that describe relaxation to equilibrium."
For more information on this research see: Role of filament annealing in the kinetics and thermodynamics of nucleated polymerization. Journal of Chemical Physics, 2014;140(21):529-539. Journal of Chemical Physics can be contacted at: Amer Inst Physics, Circulation & Fulfillment Div, 2 Huntington Quadrangle, Ste 1 N O 1, Melville, NY 11747-4501, USA. (American Institute of Physics - www.aip.org/; Journal of Chemical Physics - jcp.aip.org/)
Our news journalists report that additional information may be obtained by contacting T.C.T. Michaels, University of Cambridge, Dept. of Chem, Cambridge CB2 1EW, United Kingdom.
Keywords for this news article include: Europe, Cambridge, United Kingdom, Thermodynamics, Chemical Physics
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