New Findings from University of Hamburg Yields New Data on Nanoparticles (Controlling the physical and biological properties of highly fluorescent aqueous quantum dots using block copolymers of different size and shape)
By a News Reporter-Staff News Editor at Physics Week -- Research findings on Nanoparticles are discussed in a new report. According to news reporting from Hamburg, Germany, by VerticalNews journalists, research stated, "The phase transfer of fluorescent CdSe based quantum dots (QDs) while retaining their properties and offering some advantages concerning the stability and functionalization characteristics is an important and intensively investigated field of research. Here we report how to tune and control the properties of CdSe/CdS/ZnS core-shell-shell QDs in water, using poly(isoprene-block-ethylene oxide) (PI-b-PEO) as a versatile system of amphiphilic diblock copolymers for the micellular encapsulation of nanoparticles (NPs)."
The news correspondents obtained a quote from the research from the University of Hamburg, "We show the synthesis of a novel PI-b-(PEO)2 miktoarm star polymer and how this different architecture besides the variation of the polymers' molecular weight gives us the opportunity to control the size of the built constructs in water between 24 and 53 nm. Because of this size control, an upper limit of the construct's diameter for the cellular uptake could be determined by a systemic study with human alveolar epithelial cells (A549) and murine macrophage leukemia cell (RAW-264.7). Furthermore, fluorescence quenching experiments with copper(II) and iron(III) ions show a strong influence of the used polymer on the shielding against these ions. This enables us to control the permeability of the polymer shell from very porous shells, which allow an almost complete cation exchange up to very dense shells. These even offer the possibility to perform copper(I) catalyzed click reactions while keeping the fluorescence of the QDs. All these results underline the huge variability and controllability of the PI-b-PEO diblock copolymer system for the encapsulation and functionalization of nanoparticles for biological applications."
According to the news reporters, the research concluded: "As a general trend, it can be stated that those coatings, which were most stable against quenchers, also showed the best resistivity with respect to unspecific cellular uptake."
For more information on this research see: Controlling the physical and biological properties of highly fluorescent aqueous quantum dots using block copolymers of different size and shape. Acs Nano, 2013;7(10):9156-67. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)
Our news journalists report that additional information may be obtained by contacting J. Ostermann, Institute of Physical Chemistry, University of Hamburg , Grindelallee 117, 20146 Hamburg, Germany. Additional authors for this research include J.P. Merkl, S. Flessau, C. Wolter, A. Kornowksi, C. Schmidtke, A. Pietsch, H. Kloust, A. Feld and H. Weller.
Keywords for this news article include: Europe, Hamburg, Germany, Quantum Dots, Nanotechnology, Quantum Physics, Emerging Technologies.
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