Understanding the need for better quality and higher consistency in ion channel-expressing cell lines, and the gap that currently exists in this area, ChanTest has recently developed new cells that expand its industry-leading portfolio of validated ion channel and GPCR cell lines. ChanTest's research focuses on ion channel-expressing cell lines, as ion channels control many critical physiological functions throughout the body. Being able to control this activity creates the potential to treat a variety of human diseases.
ChanTest has validated these cells using their automated electrophysiology and fluorescent plate reader systems.
Because of their control over many critical physiological functions, ion channels are one of the most important categories of drug targets in the pharmaceutical industry. With the growing need to test the safety and efficiency of new drugs, the importance of an organized library of cell lines is critical.
ChanTest's cell and molecular biology group has developed several new or improved recombinant cells expressing ligand-gated ion channels. Two of these new products, CTN6117 (stably transfected) and CTN7117 (transiently transfected), consist of ionotropic serotonergic (5-HT3A) receptors expressed in HEK293 cells. 5-HT3A is a therapeutic target in nausea and irritable bowel syndrome. Also, new cell lines have been developed that stably express nicotinic acetylcholine receptor subtypes in CHO cells. These include a3▀4a5 (CT6024) and a2▀4 (CT6023), which are important therapeutic targets in several neurological indications, and join previously developed nicotinic a7 (CT6201) and a3▀4 (CT6021) subtype-expressing cell lines in our catalog. ChanTest has engineered all cells for optimal performance in automated patch clamp and FLIPR high throughput screening systems.
In combination with automated medium- to high-throughput functional assays, ChanTest can help organizations rapidly profile compounds across a range of ion channels. ChanTest can also help to construct and validate other cell lines in a timely and cost effective manner.
For a complete list of available cell lines, visit: http://www.chantest.com/reagents/ion-channel/cell-lines.
About ChanTest« ľ The Ion Channel Expert
ChanTest's mission is to serve the drug discovery and development needs of customers worldwide. Since its start in 1998, the Contract Research Organization has tested compounds for more than 300 global pharmaceutical and biotechnology companies. ChanTest also partners with these companies to accelerate the drug development process for the release of better, safer drugs. ChanTest offers ion channel and GPCR cell reagents, ion channel screening/profiling services, and cardiac safety services. The company's library of validated ion channel cell lines, and nonclinical cardiac risk assessment service portfolio, is the most comprehensive commercial library available today.
Because of ChanTest's influential role, along with the company's uncompromising commitment to quality, an independent survey has named ChanTest the "most trusted and most used fee-for-service provider" since 2006. ChanTest is based in
Visit http://www.chantest.com to learn more about ChanTest.
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