By a News Reporter-Staff News Editor at Science Letter -- Fresh data on Science are presented in a new report. According to news originating from Davis, California, by NewsRx correspondents, research stated, "Interaction force-distance profiles between substrate-supported membranes composed of equimolar ternary mixtures of unsaturated phosphotidylcholine (PC) lipid, saturated PC lipid, and cholesterol were determined using the surface force apparatus. Both double and single unsaturated PC lipids were studied."
Our news journalists obtained a quote from the research from the University of California, "In all cases, the membranes were slightly negatively charged, resulting in a weak, long-range electrostatic repulsion. Corroborative atomic force microscopy, zeta potential, and fluorescence microscopy measurements were used to establish that a small level of charged lipid impurities (similar to 1/400 lipid molecules) were responsible for the repulsive electrostatic interaction between the membranes. At contact, the membranes were adhesive. The magnitude of the adhesion was greater than the van der Waals interaction between pure PC membranes without cholesterol. The enhanced adhesion was primarily attributed to hydrophobic attraction due to the presence of nanoscopic membrane defects which exposed the underlying membrane leaflet."
According to the news editors, the research concluded: "The interaction force distance profiles also demonstrated that the nanoscopic defects enabled membrane restructuring in the contact region."
For more information on this research see: Interaction Forces between Ternary Lipid Bilayers Containing Cholesterol. Langmuir, 2014;30(17):4997-5004. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Langmuir - www.pubs.acs.org/journal/langd5)
The news correspondents report that additional information may be obtained from J. Kurniawan, University of California, Dept. of Chem, Davis, CA 95616, United States. Additional authors for this research include N.N. Yin, G.Y. Liu and T.L. Kuhl (see also Science).
Keywords for this news article include: Davis, Science, California, United States, North and Central America
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