News Column

Study Results from IBM Research-Zurich in the Area of Analytical Science Reported

June 13, 2014

By a News Reporter-Staff News Editor at Science Letter -- Investigators discuss new findings in Science. According to news reporting from Ruschlikon, Switzerland, by NewsRx journalists, research stated, "The microfluidic probe (MFP) is a non-contact, scanning microfluidic technology for local (bio)chemical processing of surfaces based on hydrodynamically confining nanoliter volumes of liquids over tens of micrometers. We present here a compact MFP (cMFP) that can be used on a standard inverted microscope and assist in the local processing of tissue sections and biological specimens."

The news correspondents obtained a quote from the research from IBM Research-Zurich, "The cMFP has a footprint of 175 x 100 x 140 mm(3) and can scan an area of 45 x 45 mm(2) on a surface with an accuracy of +/- 15 mu m. The cMFP is compatible with standard surfaces used in life science laboratories such as microscope slides and Petri dishes. For ease of use, we developed self-aligned mounted MFP heads with standardized 'chip-to-world' and 'chip-to-platform' interfaces. Switching the processing liquid in the flow confinement is performed within 90 s using a selector valve with a dead-volume of approximately 5 mu l. We further implemented height-compensation that allows a cMFP head to follow non-planar surfaces common in tissue and cellular ensembles. This was shown by patterning different macroscopic copper-coated topographies with height differences up to 750 mu m. To illustrate the applicability to tissue processing, 5 mu m thick M000921 BRAF V600E+ melanoma cell blocks were stained with hematoxylin to create contours, lines, spots, gradients of the chemicals, and multiple spots over larger areas. The local staining was performed in an interactive manner using a joystick and a scripting module."

According to the news reporters, the research concluded: "The compactness, user-friendliness, and functionality of the cMFP will enable it to be adapted as a standard tool in research, development and diagnostic laboratories, particularly for the interaction with tissues and cells."

For more information on this research see: A compact and versatile microfluidic probe for local processing of tissue sections and biological specimens. Review of Scientific Instruments, 2014;85(3):405-413. Review of Scientific Instruments can be contacted at: Amer Inst Physics, Circulation & Fulfillment Div, 2 Huntington Quadrangle, Ste 1 N O 1, Melville, NY 11747-4501, USA. (American Institute of Physics -; Review of Scientific Instruments -

Our news journalists report that additional information may be obtained by contacting J.F. Cors, IBM Res Zurich, CH-8803 Ruschlikon, Switzerland. Additional authors for this research include R.D. Lovchik, E. Delamarche and G.V. Kaigala (see also Science).

Keywords for this news article include: Europe, Science, Ruschlikon, Switzerland

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Source: Science Letter

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