News Column

Study Data from University of Florida Update Understanding of Nanoparticles

June 13, 2014



By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Nanoparticles. According to news reporting originating in Gainesville, Florida, by NewsRx journalists, research stated, "The use of dynamic magnetic susceptibility measurements is reported to study nanoparticle-protein interactions in situ. The technique consists of measuring the rotational diffusivity of thermally blocked magnetic nanoparticles (MNPs) in protein solutions."

The news reporters obtained a quote from the research from the University of Florida, "To illustrate the technique, the effect of nanoparticle zeta potential in carboxymethyl-dextran-coated MNPs and their interaction with model anionic and cationic proteins, such as bovine serum albumin (BSA), immunoglobulin G (IgG), fibrinogen (FIBR), apo-transferrin (TRANS), lysozyme (LYZ), and histone (HIS), in a range of protein concentrations is studied. Experiments indicate that interactions between the negatively charged particles and the negatively charged proteins BSA, IgG, FIBR, and TRANS are negligible. However, positively charged proteins LYZ and HIS readily absorb onto the nanoparticles, as evidenced by an increase in size and eventual aggregation of the particles. Onset of this effect seems to happen at a lower concentration of HIS compared with LYZ."

According to the news reporters, the research concluded: "The technique could be applied to other particle surface coatings and to particles in complex protein mixtures, such as whole blood and serum, allowing systematic in situ studies of nanoparticle-protein interactions."

For more information on this research see: In Situ Evaluation of Nanoparticle-Protein Interactions by Dynamic Magnetic Susceptibility Measurements. Particle & Particle Systems Characterization, 2014;31(5):561-570. Particle & Particle Systems Characterization can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Particle & Particle Systems Characterization - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1521-4117)

Our news correspondents report that additional information may be obtained by contacting A.C. Bohorquez, University of Florida, Dept. of Chem Engn, Gainesville, FL 32611, United States (see also Nanoparticles).

Keywords for this news article include: Florida, Peptides, Proteins, Gainesville, Amino Acids, United States, Nanotechnology, Emerging Technologies, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Science Letter


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