News Column

Researchers from Wuhan University Report Details of New Studies and Findings in the Area of Dodecanol

June 13, 2014



By a News Reporter-Staff News Editor at Science Letter -- Current study results on Dodecanol have been published. According to news reporting from Wuhan, People's Republic of China, by NewsRx journalists, research stated, "The effect of low concentrations of sodium dodecyl sulfate (SDS) on the separation of palonosetron hydrochloride (PALO) stereoisomers by micellar electrokinetic chromatography (MEKC) has been investigated. It was found that the addition of SDS prolongs the migration time and the migration order of four stereoisomers changes regularly with the SDS concentration."

The news correspondents obtained a quote from the research from Wuhan University, "Good separations for all the four stereoisomers were achieved at appropriate SOS concentration. The effect of SOS on the electromigration (mobilities) of PALO stereoisomers has been studied, in order to explain its effect on the separation by MEKC. It was found that low concentrations of SDS added into the separation media forms negatively charged complexes with PALO stereoisomers and hence reverses their electromigration direction. Furthermore, the migration order between two enantiomeric pairs is also reversed because the enantiomeric pair with a bigger positive mobility than that of another pair turns to have a bigger negative mobility when bound with SOS. Based on these results, the effect of SDS on the MEKC separation of PALO stereoisomers was elucidated reasonably."

According to the news reporters, the research concluded: "The performance of the developed chiral MEKC method was validated by the analysis of a real sample."

For more information on this research see: Effect of low concentration sodium dodecyl sulfate on the electromigration of palonosetron hydrochloride stereoisomers in micellar electrokinetic chromatography. Journal of Chromatography A, 2014;1342():86-91. Journal of Chromatography A can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Chromatography A - www.elsevier.com/wps/product/cws_home/502688)

Our news journalists report that additional information may be obtained by contacting S.Q. Hu, Wuhan University, Coll Chem & Mol Sci, Wuhan 430072, People's Republic of China. Additional authors for this research include G.X. Wang, W.B. Guo, X.M. Guo and M. Zhao (see also Dodecanol).

Keywords for this news article include: Asia, Wuhan, Dodecanol, Sulfur Acids, Nanotechnology, Sulfonic Acids, Electrokinetics, Alkanesulfonates, Sulfur Compounds, Emerging Technologies, Sodium Dodecyl Sulfate, People's Republic of China

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Source: Science Letter