News Column

Investigators at University Hospital Detail Findings in Epithelial Cells

June 13, 2014

By a News Reporter-Staff News Editor at Science Letter -- Current study results on Epithelial Cells have been published. According to news originating from Bern, Switzerland, by NewsRx correspondents, research stated, "Many advances have been made in recent years in cell culture models of the epithelial barrier of the lung from simple monolayers to complex 3-D systems employing different cell types. However, the vast majority of these models still present a static air liquid interface which is unrealistic given the dynamic nature of breathing."

Our news journalists obtained a quote from the research from University Hospital, "We present here a method where epithelial lung cells are integrated into a system, the captive bubble surfactometer, which allows the cyclical compression and expansion of the surfactant film at the air liquid interface, thus modeling the dynamics of breathing. We found that cellular uptake of deposited gold nanoparticles was significantly increased under the dynamic (breathing) conditions of compression and expansion as compared to static conditions."

According to the news editors, the research concluded: "The method could be very useful for studying nanoparticle alveolar lung cell interactions under breathing conditions for applications in nano-medicine and toxicology."

For more information on this research see: Modeling Nanoparticle-Alveolar Epithelial Cell Interactions under Breathing Conditions Using Captive Bubble Surfactometry. Langmuir, 2014;30(17):4924-4932. Langmuir can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; Langmuir -

The news correspondents report that additional information may be obtained from D. Schurch, University Hospital Bern, CH-3010 Bern, Switzerland. Additional authors for this research include D. Vanhecke, M.J.D. Clift, D. Raemy, D.J. de Aberasturi, W.J. Parak, P. Gehr, A. Petri-Fink and B. Rothen-Rutishauser (see also Epithelial Cells).

Keywords for this news article include: Bern, Europe, Switzerland, Epithelial Cells

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Source: Science Letter

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