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Study Data from College of Basic Medical Sciences Update Understanding of Nanoparticles

June 13, 2014



By a News Reporter-Staff News Editor at Drug Week -- Investigators discuss new findings in Nanoparticles. According to news originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Fullerene C-60 nanoparticles (C-60 NPs) have been widely applied in many fields due to their excellent physical and chemical properties. As production and applications of C60 NPs expand, public concern about the potential risk to human health has also risen."

Our news journalists obtained a quote from the research from the College of Basic Medical Sciences, "The toxicity of C-60 NPs was evaluated by the CCK-8 assay using the cultured human epithelial cell line A549. Cellular uptake of the C-60 NPs was observed by TEM imaging. In our findings, C-60 NPs could readily enter A549 cells and showed no significant toxicity. Exposure of cultured A549 cells to C-60 NPs led to an increase of intracellular reactive oxygen species (ROS) while glutathione reductase activity was probably activated to generate more GSH to maintain a cellular oxidation-reduction equilibrium."

According to the news editors, the research concluded: "The A549 cells responded to the ROS increases through the inauguration of autophagic responses, aimed at restoring cellular health and equilibrium."

For more information on this research see: Effects of fullerene C-60 nanoparticles on A549 cells. Environmental Toxicology and Pharmacology, 2014;37(2):656-661. Environmental Toxicology and Pharmacology can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Environmental Toxicology and Pharmacology - www.elsevier.com/wps/product/cws_home/523024)

The news correspondents report that additional information may be obtained from F.D. Wang, Second Military Med Univ, Dept. of Biophys, Coll Basic Med Sci, Shanghai 200433, People's Republic of China. Additional authors for this research include C. Jin, H. Liang, Y. Tang, H. Zhang and Y.J. Yang (see also Nanoparticles).

Keywords for this news article include: Asia, Carbon, Shanghai, Fullerenes, Nanotechnology, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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