By a News Reporter-Staff News Editor at Women's Health Weekly -- Research findings on Oncology are discussed in a new report. According to news reporting originating in Seoul, South Korea, by NewsRx journalists, research stated, "The clinical efficacy of conventional chemotherapeutic agent, methotrexate (MTX), can be limited by its very short plasma half-life, the drug resistance, and the high dosage required for cancer cell suppression. In this study, a new drug delivery system is proposed to overcome such limitations."
The news reporters obtained a quote from the research from Ewha Woman's University, "To realize such a system, MTX was intercalated into layered double hydroxides (LDHs), inorganic drug delivery vehicle, through a co-precipitation route to produce a MTX-LDH nanohybrid with an average particle size of approximately 130 nm. Biodistribution studies in mice bearing orthotopic human breast tumors revealed that the tumor-to-liver ratio of MTX in the MTX-LDH-treated-group was 6-fold higher than that of MTX-treated-one after drug treatment for 2 hr. Moreover, MTX-LDH exhibited superior targeting effect resulting in high antitumor efficacy inducing a 74.3% reduction in tumor volume compared to MTX alone, and as a consequence, significant survival benefits. Annexin-V and propidium iodine dual staining and TUNEL analysis showed that MTX-LDH induced a greater degree of apoptosis than free MTX."
According to the news reporters, the research concluded: "Taken together, our data demonstrate that a new MTX-LDH nanohybrid exhibits a superior efficacy profile and improved distribution compared to MTX alone and has the potential to enhance therapeutic efficacy via inhibition of tumor proliferation and induction of apoptosis."
For more information on this research see: Inorganic nanovehicle targets tumor in an orthotopic breast cancer model. Scientific Reports, 2014;4():4430. (Nature Publishing Group - www.nature.com/; Scientific Reports - www.nature.com/srep/)
Our news correspondents report that additional information may be obtained by contacting G. Choi, Center for Intelligent Nano-Bio Materials (CINBM), Dept. of Chemistry and Nano Science (Ewha Global Top 5 program-2011) and Dept. of Bioinspired Science, Ewha Womans University, Seoul 120-750, South Korea. Additional authors for this research include O.J. Kwon, Y. Oh, C.O. Yun and J.H Choy (see also Oncology).
Keywords for this news article include: Asia, Seoul, Oncology, South Korea, Therapeutics, Breast Cancer, Women's Health, Drug Delivery Systems.
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