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Iranians help expedite prostate brachytherapy

June 28, 2014

Science & Technology Desk

Researchers at North Khorasan Medical University in Bojnourd, Iran, in association with their counterparts at the Comprehensive Cancer Centers of Nevada, Las Vegas, USA, boosted absorption of radiation in tumors by using nanoparticles in prostate brachytherapy.

ProstaSeed 125I brachytherapy source was simulated using MCNPX code.

Dose enhancement factors (DEFs) were calculated for Fe2O3, Ag, Gd, Pt and Au nanoparticles with different concentrations.

No general trend in DEF with an increasing concentration of nanoparticles was observed. However, DEF was highest for 30 mg/ml concentration of Au.

The presence of nanoparticles in a prostate tumor increases the dose inside tumor and decreases the dose outside it and the treatment time can be decreased due to dose enhancement.

Results of the research showed that nanoparticles can be a useful tool in prostate brachytherapy.

Au nanoparticles of higher concentrations can be more useful for this purpose when compared to other nanoparticles.

Monte Carlo methods (or Monte Carlo experiments) are a broad class of computational algorithms that rely on repeated random sampling to obtain numerical results.

Typically, one runs simulations many times over to obtain the distribution of an unknown probabilistic entity.

Brachytherapy, also known as internal radiotherapy, is a form of radiotherapy where a radiation source is placed inside or next to the area requiring treatment. It is commonly used as an effective treatment for cervical, prostate, breast and skin cancer, and can also be used to treat tumors in many other body sites.

Iranians help expedite prostate brachytherapy

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Source: Iran Daily

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