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Studies from X.L. Zhao and Co-Researchers Update Current Data on Chemical Engineering (Preparation and in vivo evaluation of ligand-conjugated...

July 2, 2014



Studies from X.L. Zhao and Co-Researchers Update Current Data on Chemical Engineering (Preparation and in vivo evaluation of ligand-conjugated polymeric microbubbles as targeted ultrasound contrast agents)

By a News Reporter-Staff News Editor at Journal of Engineering -- Researchers detail new data in Chemical Engineering. According to news reporting originating from Harbin, People's Republic of China, by VerticalNews correspondents, research stated, "Targeted ultrasound contrast agents (UCAs) offer new opportunities to enhance the capabilities of diagnostic ultrasound imaging to detect pathological tissue. Poly (D, L-lactic-co-glycolic acid) (PLGA) UCAs based on microbubbles (MBs) were developed to target inflamed plaque, to aid in the diagnosis of atherosclerosis."

Our news editors obtained a quote from the research, "A conjugation strategy was adopted using PLGA shelled MBs to enable localized targeting on atherosclerotic plaque by modifying the surface of these polymeric MBs with anti-ICAM-1. In addition, several investigations were carried out to determine the morphology and performance of the prepared MBs, including surface morphology, size distribution and conjugation efficiency analysis. Fluorescence microscopy and flow cytometry analysis showed a specific adhesion and high conjugation efficiency of targeting ligands to MBs."

According to the news editors, the research concluded: "Furthermore, the conjugated MBs were applied in vivo ultrasound targeted imaging and the results demonstrated the availability of conjugated MBs as a highly efficient ultrasound system in targeted ultrasound imaging and in noninvasive biological research."

For more information on this research see: Preparation and in vivo evaluation of ligand-conjugated polymeric microbubbles as targeted ultrasound contrast agents. Colloids and Surfaces A-Physicochemical and Engineering Aspects, 2014;452():59-64. Colloids and Surfaces A-Physicochemical and Engineering Aspects can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands.

The news editors report that additional information may be obtained by contacting X.L. Zhao, Chest Hosp Harbin, Dept. of Ultrasound, Harbin 150056, People's Republic of China. Additional authors for this research include X.Y. Zhang, L. Xue, J. Wang, B.Z. Shen, C.Y. Luo and Q.Q. Wang.

Keywords for this news article include: Asia, Harbin, Chemical Engineering, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Journal of Engineering


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