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Studies from Copenhagen University Hospital Have Provided New Data on Bioinformatics (Modeling tissue contamination to improve molecular...

July 1, 2014



Studies from Copenhagen University Hospital Have Provided New Data on Bioinformatics (Modeling tissue contamination to improve molecular identification of the primary tumor site of metastases)

By a News Reporter-Staff News Editor at Information Technology Newsweekly -- Research findings on Bioinformatics are discussed in a new report. According to news originating from Copenhagen, Denmark, by VerticalNews correspondents, research stated, "Contamination of a cancer tissue by the surrounding benign (non-cancerous) tissue is a concern for molecular cancer diagnostics. This is because an observed molecular signature will be distorted by the surrounding benign tissue, possibly leading to an incorrect diagnosis."

Our news journalists obtained a quote from the research from Copenhagen University Hospital, "One example is molecular identification of the primary tumor site of metastases because biopsies of metastases typically contain a significant amount of benign tissue. A model of tissue contamination is presented. This contamination model works independently of the training of a molecular predictor, and it can be combined with any predictor model. The usability of the model is illustrated on primary tumor site identification of liver biopsies, specifically, on a human dataset consisting of microRNA expression measurements of primary tumor samples, benign liver samples and liver metastases. For a predictor trained on primary tumor and benign liver samples, the contamination model decreased the test error on biopsies from liver metastases from 77 to 45%."

According to the news editors, the research concluded: "A further reduction to 34% was obtained by including biopsies in the training data."

For more information on this research see: Modeling tissue contamination to improve molecular identification of the primary tumor site of metastases. Bioinformatics, 2014;30(10):1417-1423. Bioinformatics can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Bioinformatics - bioinformatics.oxfordjournals.org)

The news correspondents report that additional information may be obtained from M. Vincent, Copenhagen Univ Hosp, Rigshospitalet, Center Genom Med, DK-2100 Copenhagen, Denmark. Additional authors for this research include K. Perell, F.C. Nielsen, G. Daugaard and N.R. Hansen.

Keywords for this news article include: Europe, Denmark, Copenhagen, Bioinformatics

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Information Technology Newsweekly


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