Studies from Copenhagen University Hospital Have Provided New Data on Bioinformatics (Modeling tissue contamination to improve molecular identification of the primary tumor site of metastases)
By a News Reporter-Staff News Editor at Information Technology Newsweekly -- Research findings on Bioinformatics are discussed in a new report. According to news originating from Copenhagen, Denmark, by VerticalNews correspondents, research stated, "Contamination of a cancer tissue by the surrounding benign (non-cancerous) tissue is a concern for molecular cancer diagnostics. This is because an observed molecular signature will be distorted by the surrounding benign tissue, possibly leading to an incorrect diagnosis."
Our news journalists obtained a quote from the research from Copenhagen University Hospital, "One example is molecular identification of the primary tumor site of metastases because biopsies of metastases typically contain a significant amount of benign tissue. A model of tissue contamination is presented. This contamination model works independently of the training of a molecular predictor, and it can be combined with any predictor model. The usability of the model is illustrated on primary tumor site identification of liver biopsies, specifically, on a human dataset consisting of microRNA expression measurements of primary tumor samples, benign liver samples and liver metastases. For a predictor trained on primary tumor and benign liver samples, the contamination model decreased the test error on biopsies from liver metastases from 77 to 45%."
According to the news editors, the research concluded: "A further reduction to 34% was obtained by including biopsies in the training data."
For more information on this research see: Modeling tissue contamination to improve molecular identification of the primary tumor site of metastases. Bioinformatics, 2014;30(10):1417-1423. Bioinformatics can be contacted at: Oxford Univ Press, Great Clarendon St, Oxford OX2 6DP, England. (Oxford University Press - www.oup.com/; Bioinformatics - bioinformatics.oxfordjournals.org)
The news correspondents report that additional information may be obtained from M. Vincent, Copenhagen Univ Hosp, Rigshospitalet, Center Genom Med, DK-2100 Copenhagen, Denmark. Additional authors for this research include K. Perell, F.C. Nielsen, G. Daugaard and N.R. Hansen.
Keywords for this news article include: Europe, Denmark, Copenhagen, Bioinformatics
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