The patent's inventors are Moshe, Meir H. (
This patent was filed on
From the background information supplied by the inventors, news correspondents obtained the following quote: "Conventional devices for delivering therapeutic energy to tissue include a handle and a probe coupled to the handle. The probe contains at least one electrode to which an electrical power source is coupled. The power source allows the electrode to deliver the therapeutic energy to a targeted tissue, thereby causing ablation of the tissue.
"In certain applications, it is desirable to provide a probe having a relatively small cross-section, for example 1 cm in diameter or less, wherein the electrodes are moved to a compact state to a configuration where the distance between the distal section of any two electrodes is smallest, so as to be placeable within a position inside of the outermost dimension of the probe. Prior art devices have utilized flexible materials having shape memory (such as nickel titanium, also known as 'Nitinol') for the electrodes in order to accomplish this. However as the distal sections of the electrodes are moved from a compact position to a more expanded position where the distance between at least distal sections of two electrodes becomes greater, it is difficult to keep such electrodes in proper alignment if they are composed of flexible materials. Further, it is often difficult or sometimes not possible to place the electrodes in the correct location of the tissue to be ablated.
"Applications of a probe that could be utilized as described ideally would involve the emerging technology of Irreversible Electroporation (IRE). Irreversible electroporation (IRE) involves the use of electrical pulses to target tumor tissue in the range of microseconds to milliseconds that can lead to non-thermally produced defects in the cell membrane that are nanoscale in size. These defects can lead to a disruption of homeostasis of the cell membrane, thereby causing irreversible cell membrane permeabilization which induces cell necrosis, without raising the temperature of the tumor ablation zone. During IRE ablation, connective tissue and scaffolding structures are spared, thus allowing the surrounding bile ducts, blood vessels, and connective tissue to remain intact. With nonthermal IRE (hereinafter also called non-thermal IRE), cell death is mediated through a nonthermal mechanism, so the heat sink problem associated with many ablation techniques is nullified. Therefore the advantages of IRE to allow focused treatment with tissue sparing and without thermal effects can be used effectively in conjunction with thermal treatment such as RF that has been proven effective to prevent track seeding; this will also allow (in this example embodiment) the user to utilize determined RF levels (or long-DC pulses) leading to in some cases ablation and in some cases coagulation of blood vessels of all sizes encountered during treatment. IRE can be utilized effectively with known techniques of thermal damage including mediating tumor cell death and bringing about coagulation along a tissue track.
"Therefore, it would be desirable to provide a device and method which includes electrodes that can be placed within a relatively small diameter by being placed in a compact position to a more expanded position where the distance between at least distal sections of two electrodes becomes greater, and then returned to the compact position while the distal sections of the electrodes remain in parallel with each other. With some therapies, parallel electrodes are needed; parallel embodiments are in certain cases better than curved flexible electrodes such as in use with hard surfaces, tumors, or cancers. Maintaining a parallel orientation can be critical to treatment success. Additionally, this device could be used to mediate irreversible electroporation separately or in conjunction with reversible electroporation, long-DC pulses, and Radio-Frequency (RF) technologies which provides additional advantages of treatment when used in conjunction with features such as the parallel electrode orientation."
Supplementing the background information on this patent, VerticalNews reporters also obtained the inventors' summary information for this patent: "Throughout the present teachings, any and all of the one, two, or more features and/or components disclosed or suggested herein, explicitly or implicitly, may be practiced and/or implemented in any combinations of two, three, or more thereof, whenever and wherever appropriate as understood by one of ordinary skill in the art. The various features and/or components disclosed herein are all illustrative for the underlying concepts, and thus are non-limiting to their actual descriptions. Any means for achieving substantially the same functions are considered as foreseeable alternatives and equivalents, and are thus fully described in writing and fully enabled. The various examples, illustrations, and embodiments described herein are by no means, in any degree or extent, limiting the broadest scopes of the claimed inventions presented herein or in any future applications claiming priority to the instant application.
"Disclosed herein are devices for delivering therapeutic energy for destruction and/or removal of undesirable living biological tissues and methods of using such, particularly for treatment. In particular, according to the principles of the present invention, a device for delivering therapeutic energy to tissue is provided. The device includes a housing and a rotating device coupled to the housing. The device includes a plurality of electrodes, each electrode including: (i) a proximal section longitudinally extending from the within the housing and having a longitudinal axis; (ii) an intermediate section extending from the proximal section; and (iii) a distal section extending longitudinally from the intermediate section. The rotating device is coupled to the proximal sections of the plurality of electrodes and adapted to rotate the electrodes to move the distal section of the electrodes so that distance between at least two electrodes changes, so that the electrodes can be placed in a compact position or an expanded position or can be placed at any configuration, referring to any radial state between fully compacted and fully expanded."
For the URL and additional information on this patent, see: Moshe, Meir H.; Douglass,
Keywords for this news article include:
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