New Chromatography Findings from Sichuan University Described (Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations)
By a News Reporter-Staff News Editor at Science Letter -- Researchers detail new data in Science. According to news reporting originating from Chengdu, People's Republic of China, by NewsRx correspondents, research stated, "Drug impurity profiling and identification are carried out along with the drug discovery process. Due to its inherent low concentration in drug products, the isolation and purification of impurities present a challenge to drug development processes."
Our news editors obtained a quote from the research from Sichuan University, "In our development of honokiol and quercetin as anticancer drug candidates, counter-current chromatography (CCC) and preparative HPLC were used for the impurity profiling and identification of honokiol and quercetin. Several performance parameters such as separation column volume, maximum sample loading, separation time, solvent consumption and sample throughput were investigated in order to compare the separation efficiency. We found that the sample loading capacity and therefore the throughput of preparative HPLC were not satisfactory, while CCC provided larger sample loading (especially for a sample with poor solubility), consumed less solvent and produced higher throughput than preparative HPLC."
According to the news editors, the research concluded: "Six impurities of honokiol including one new compound were isolated in the present work."
For more information on this research see: Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations. Journal of Chromatography A, 2014;1344():51-58. Journal of Chromatography A can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Chromatography A - www.elsevier.com/wps/product/cws_home/502688)
The news editors report that additional information may be obtained by contacting S.C. Li, Sichuan University, State Key Lab Biotherapy, West China Hosp, West China Med Sch, Chengdu 610041, Sichuan, People's Republic of China. Additional authors for this research include W.W. Wang, H. Tang, K. Chen, J.H. Yang, L.H. He, H.Y. Ye, A.H. Peng and L.J. Chen (see also Science).
Keywords for this news article include: Asia, Chengdu, Science, Imaging Technology, People's Republic of China, High-Performance Liquid Chromatography
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