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Study Results from Oncology Institute Provide New Insights into Radiotherapy (Critical appraisal of RapidArc radiosurgery with flattening filter free...

July 2, 2014



Study Results from Oncology Institute Provide New Insights into Radiotherapy (Critical appraisal of RapidArc radiosurgery with flattening filter free photon beams for benign brain lesions in comparison to GammaKnife: a treatment planning study)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news originating from Bellinzona, Switzerland, by NewsRx correspondents, research stated, "To evaluate the role of RapidArc (RA) for stereotactic radiosurgery (SRS) of benign brain lesions in comparison to GammaKnife (GK) based technique. Twelve patients with vestibular schwannoma (VS, n = 6) or cavernous sinus meningioma (CSM, n = 6) were planned for both SRS using volumetric modulated arc therapy (VMAT) by RA. 104 MV flattening filter free photon beams with a maximum dose rate of 2400 MU/min were selected."

Our news journalists obtained a quote from the research from Oncology Institute, "Data were compared against plans optimised for GK. A single dose of 12.5 Gy was prescribed. The primary objective was to assess treatment plan quality. Secondary aim was to appraise treatment efficiency. For VS, comparing best GK vs. RA plans, homogeneity was 51.7 +/- 3.5 vs. 6.4 +/- 1.5%; Paddick conformity Index (PCI) resulted 0.81 +/- 0.03 vs. 0.84 +/- 0.04. Gradient index (PGI) was 2.7 +/- 0.2 vs. 3.8 +/- 0.6. Mean target dose was 17.1 +/- 0.9 vs. 12.9 +/- 0.1 Gy. For the brain stem, D-1cm3 was 5.1 +/- 2.0 Gy vs 4.8 +/- 1.6 Gy. For the ipsilateral cochlea, D-0.1cm3 was 1.7 +/- 1.0 Gy vs. 1.8 +/- 0.5 Gy. For CSM, homogeneity was 52.3 +/- 2.4 vs. 12.4 +/- 0.6; PCI: 0.86 +/- 0.05 vs. 0.88 +/- 0.05; PGI: 2.6 +/- 0.1 vs. 3.8 +/- 0.5; D-1cm3 to brain stem was 5.4 +/- 2.8 Gy vs. 5.2 +/- 2.8 Gy; D-0.1cm3 to ipsi-lateral optic nerve was 4.2 +/- 2.1 vs. 2.1 +/- 1.5 Gy; D-0.1cm3 to optic chiasm was 5.9 +/- 3.1 vs. 4.5 +/- 2.1 Gy. Treatment time was 53.7 +/- 5.8 (64.9 +/- 24.3) minutes for GK and 4.8 +/- 1.3 (5.0 +/- 0.7) minutes for RA for schwannomas (meningiomas)."

According to the news editors, the research concluded: "SRS with RA and FFF beams revealed to be adequate and comparable to GK in terms of target coverage, homogeneity, organs at risk sparing with some gain in terms of treatment efficiency."

For more information on this research see: Critical appraisal of RapidArc radiosurgery with flattening filter free photon beams for benign brain lesions in comparison to GammaKnife: a treatment planning study. Radiation Oncology, 2014;9():18-26. Radiation Oncology can be contacted at: Biomed Central Ltd, 236 Grays Inn Rd, Floor 6, London WC1X 8HL, England. (BioMed Central - www.biomedcentral.com/; Radiation Oncology - www.ro-journal.com)

The news correspondents report that additional information may be obtained from U. Abacioglu, Oncol Inst Southern Switzerland, Medical Phys Unit, CH-6504 Bellinzona, Switzerland. Additional authors for this research include Z. Ozen, M. Yilmaz, A. Arifoglu, B. Gunhan, N. Kayalilar, S. Peker, M. Sengoz, S. Gurdalli and L. Cozzi (see also Drugs and Therapies).

Keywords for this news article include: Europe, Bellinzona, Brain Stem, Switzerland, Radiosurgery, Radiotherapy, Drugs and Therapies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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