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Study Results from Nanchang University Broaden Understanding of Peptides and Proteins (Triolein and Trilinolein Ameliorate Oxidized Low-Density...

July 4, 2014



Study Results from Nanchang University Broaden Understanding of Peptides and Proteins (Triolein and Trilinolein Ameliorate Oxidized Low-Density Lipoprotein-Induced Oxidative Stress in Endothelial Cells)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Proteins. According to news reporting originating in Nanchang, People's Republic of China, by NewsRx journalists, research stated, "Uptake of oxidized low-density lipoprotein by endothelial cells is a critical step for the initiation of atherosclerosis. Triacylglycerol uptake in these cells is understood to be a part of the process."

The news reporters obtained a quote from the research from Nanchang University, "The present investigation, comparison among the effects of simple acylglycerol, including tristearin, triolein, and trilinolein, upon oxidized low-density lipoprotein -induced oxidative stress was undertaken. Results indicated that trilinolein (78 % +/- 0.02) and triolein (90 % +/- 0.01) increased cell viability of endothelial cells exposed to oxidized low-density lipoprotein, whereas tristearin decreased the cell viability (55 % +/- 0.03) (P < 0.05). Oxidized low-density lipoprotein treatment significantly increased apoptosis (23 %), compared to cells simultaneously exposed to tri-linolein (19 %) or triolein (16 %), where apoptosis was reduced (P < 0.05). On the other hand, exposure to tri-stearin further increased oxidized low-density lipoprotein - induced cell apoptosis (34 %). Treatment with trilinolein or triolein on oxidized low-density lipoprotein -stimulated endothelial cells inhibited the expression of ICAM-1 and E-selectin mRNA. Moreover, both trilinolein and triolein demonstrated a strong antioxidant response to oxidative stress caused by oxidized low-density lipoprotein."

According to the news reporters, the research concluded: "Taken together, the results indicate trilinolein and triolein possess anti-inflammatory properties, which are mediated via the antioxidant defense system."

For more information on this research see: Triolein and Trilinolein Ameliorate Oxidized Low-Density Lipoprotein-Induced Oxidative Stress in Endothelial Cells. Lipids, 2014;49(5):495-504. Lipids can be contacted at: Springer Heidelberg, Tiergartenstrasse 17, D-69121 Heidelberg, Germany. (Springer - www.springer.com; Lipids - www.springerlink.com/content/0024-4201/)

Our news correspondents report that additional information may be obtained by contacting T. Luo, Nanchang University, Inst Adv Study, Nanoscale Sci & Technol Lab, Nanchang 330047, People's Republic of China. Additional authors for this research include Z.Y. Deng, X.P. Li, H. Rao and Y.W. Fan (see also Proteins).

Keywords for this news article include: Asia, Lipids, Nanchang, Apoptosis, Lipoproteins, Endothelial Cells, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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