Study Findings on Nanotechnology Are Outlined in Reports from Hokkaido University (Complete ON/OFF Photoswitching of the Motility of a Nanobiomolecular Machine)
By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Nanotechnology is the subject of a report. According to news reporting out of Hokkaido, Japan, by NewsRx editors, research stated, "To apply motor proteins as natural nanomolecular machines to transporting systems in nanotechnology, complete temporal control over ON/OFF switching of the motility is necessary. We have studied the photoresponsive inhibition properties of azobenzene-tethered peptides for regulation of kinesin-microtubule motility."
Our news journalists obtained a quote from the research from Hokkaido University, "Although a compound containing a peptide having an amino acid sequence derived from the kinesin's C-terminus (a known inhibitor of kinesin's motor domain) and also featuring a terminal azobenzene unit exhibited an inhibition effect, the phototunability of this behavior upon irradiation with UV or visible light was only moderate. Unexpectedly, newly synthesized peptides featuring the reverse sequence of amino acids of the C-terminus of kinesin exhibited excellent photoresponsive inhibition. In particular, azobenzene-CONH-IPKAIQASHGR completely stopped and started the motility of kinesin-microtubules in Its trans- and cis-rich states, respectively, obtained after irradiation with visible and UV light, respectively. A gliding motility system containing this photoresponsive Inhibitor allowed in situ control of the motion of microtubules on a kinesin-coated glass substrate."
According to the news editors, the research concluded: "It is expected that the present results on the photoresponsive nanomotor system open up new opportunities to design nanotransportation systems."
For more information on this research see: Complete ON/OFF Photoswitching of the Motility of a Nanobiomolecular Machine. ACS Nano, 2014;8(5):4157-4165. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news journalists report that additional information may be obtained by contacting K.R.S. Kumar, Hokkaido University, Res Inst Elect Sci, Kita Ku, Sapporo, Hokkaido 0010020, Japan. Additional authors for this research include T. Kamei, T. Fukaminato and N. Tamaoki (see also Nanotechnology).
Keywords for this news article include: Asia, Japan, Hokkaido, Nanotechnology
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