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Study Findings from National Institute of Technology Broaden Understanding of Glycoside Hydrolases (Zinc Oxide Nanoparticles Modulates the Production...

July 1, 2014



Study Findings from National Institute of Technology Broaden Understanding of Glycoside Hydrolases (Zinc Oxide Nanoparticles Modulates the Production of beta-Glucosidase and Protects its Functional State Under Alcoholic Condition in ...)

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Enzymes and Coenzymes are presented in a new report. According to news reporting originating in Rourkela, India, by NewsRx journalists, research stated, "In the present investigation, we have investigated the effect of zinc oxide nanoparticles (ZnONP) on the production of beta-glucosidase (BGL) in Saccharomyces cerevisiae under various conditions. ZnONP was synthesized chemically and characterized using various standard techniques."

The news reporters obtained a quote from the research from the National Institute of Technology, "The results revealed that yeast culture administered with 5 mM ZnONP enhanced the intracellular BGL activity up to 28 % compared to control with simultaneous growth of cells. However, at a higher dose of ZnONP (10 and 15 mM), both the activity of the enzyme and yeast growth was dropped. When yeast cells were grown in alcoholic medium (2, 5, and 10 % ethanol), the growth was found inhibited with substantial reduction of intracellular BGL activity. Interestingly, the administration of ZnONP further inhibited the cell growth, however, suppressed the alcoholic effect on enzyme activity. Moreover, under the same condition, ZnONP enhanced the biological activity of the enzyme in cells, indicated a higher yield of BGL production. When the mechanism of ZnONP-mediated cell growth inhibition was investigated, N-acetylcysteine (NAC)-based cell growth study proved that reactive oxygen species (ROS) was not the sole cell death mechanism induced by ZnONP, indicating a second mechanism of cell death."

According to the news reporters, the research concluded: "Our findings provide a new insight on the potential application of ZnONP as an external supplement to enhance the active production of BGL like important industrial enzyme in S. cerevisiae in both normal and alcohol stressed condition as well as to produce baker's yeast in higher amount."

For more information on this research see: Zinc Oxide Nanoparticles Modulates the Production of beta-Glucosidase and Protects its Functional State Under Alcoholic Condition in Saccharomyces cerevisiae. Applied Biochemistry and Biotechnology, 2014;173(1):155-166. Applied Biochemistry and Biotechnology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Applied Biochemistry and Biotechnology - www.springerlink.com/content/0273-2289/)

Our news correspondents report that additional information may be obtained by contacting D.K. Ban, Natl Inst Technol Rourkela, Dept. of Biotechnol & Med Engn, Struct Biol & Nanomed Lab, Rourkela 769008, Odisha, India (see also Enzymes and Coenzymes).

Keywords for this news article include: Asia, India, Rourkela, Chemicals, Chemistry, Zinc Oxide, Glucosidases, Nanoparticle, Life Sciences, Nanotechnology, Zinc Compounds, Saccharomycetales, Saccharomycetaceae, Glycoside Hydrolases, Emerging Technologies, Enzymes and Coenzymes, Saccharomyces cerevisiae

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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