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Study Findings from Nanjing University Broaden Understanding of Pharmacokinetics (Pharmacokinetic properties of arsenic species after oral...

July 2, 2014



Study Findings from Nanjing University Broaden Understanding of Pharmacokinetics (Pharmacokinetic properties of arsenic species after oral administration of Sargassum pallidum extract in rats using an HPLC-HG-AFS method)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Pharmacokinetics are discussed in a new report. According to news reporting from Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "Sargassum pallidum is one of the Traditional Chinese Medicine widely used for phlegm elimination and detumescence. Arsenic is present in high concentration in seaweed belonging to the genus Sargassum."

The news correspondents obtained a quote from the research from Nanjing University, "Therefore, the consumption of S. pallidum is a route of exposure to arsenic. Since the toxicity of arsenic is highly dependent on its chemical speciation, the determination of total arsenic is not adequate to assess the risks. Here, a high performance liquid chromatography-hydride generation-atomic fluorescence spectrometry (HPLC-HG-AFS) was developed for determination of the common arsenic species including arsenite [As(III)], dimethylarsinate (DMA), methylarsonate (MMA) and arsenate [As(V)] simultaneously. This method was applied to study the pharmacokinetic profile of these arsenic species in rats after oral administration of S. pallidum extract at different doses. The described assay was validated for limit of quantification, linearity, intra-day and inter-day precisions, accuracy, extraction recovery and stability according to the FDA validation guidelines. As(III) or MMA was not detected in any samples collected at all time points using the present HPLC-HG-AFS method. As(V) and DMA in the S. pallidum could be readily absorbed and eliminated in rats. A trend of dose-dependence was shown for DMA and As(V) in the drug concentration-time profiles."

According to the news reporters, the research concluded: "This study would be helpful for the apprehension of the action mechanism and clinical application of medicinal seaweeds."

For more information on this research see: Pharmacokinetic properties of arsenic species after oral administration of Sargassum pallidum extract in rats using an HPLC-HG-AFS method. Journal of Pharmaceutical and Biomedical Analysis, 2014;96():213-219. Journal of Pharmaceutical and Biomedical Analysis can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Pharmaceutical and Biomedical Analysis - www.elsevier.com/wps/product/cws_home/525434)

Our news journalists report that additional information may be obtained by contacting Y. Cao, Nanjing Univ Chinese Med, Natl & Local Collaborat Engn Center Chinese Med Reso, Nanjing 210046, Jiangsu, People's Republic of China. Additional authors for this research include J.A. Duan, J.M. Guo, W.X. Li and W.W. Tao (see also Pharmacokinetics).

Keywords for this news article include: Asia, Pharmaceuticals, Jiangsu, Therapy, Pharmacokinetics, Oral Administration, People's Republic of China, Drug Administration Routes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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