Study Data from University of Liege Provide New Insights into Liposomes (Liposome electrokinetic chromatography based in vitro model for early screening of the drug-induced phospholipidosis risk)
By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news reporting originating in Liege, Belgium, by NewsRx journalists, research stated, "Drug-induced phospholipidosis (PLD) is a storage disorder of lysosomes characterized by the excessive accumulation of phospholipids as a result of improper medical treatments. Although few evidences have supported that PLD can induce significant pathological consequences, this potential toxicity indeed can put off the drug discovery process."
The news reporters obtained a quote from the research from the University of Liege, "In this research, a high-throughput Liposome electrokinetic chromatography (LEKC) method was validated to evaluate the PLD risk of drug candidates by screening drug-phospholipid interaction, which correlates to the phospholipidosis inducing risk. A statistical analysis based on the Spearman's correlation test showed that the retention factors (log k) of the tested drugs in the LEKC system and the literature reported in vivo and in vitro PLD data were highly correlated. In order to investigate the predictability of LEKC, the effect of liposome composition such as the molar ratio of phospholipids and the addition of cholesterol were also discussed in this study."
According to the news reporters, the research concluded: "The results indicated that the LEKC method could offer a fast, reliable and cost-effective screening tool for early prediction of the PLD inducing potential of drug candidates."
For more information on this research see: Liposome electrokinetic chromatography based in vitro model for early screening of the drug-induced phospholipidosis risk. Journal of Pharmaceutical and Biomedical Analysis, 2014;96():263-271. Journal of Pharmaceutical and Biomedical Analysis can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Pharmaceutical and Biomedical Analysis - www.elsevier.com/wps/product/cws_home/525434)
Our news correspondents report that additional information may be obtained by contacting T.T. Wang, University of Liege, Dept. of Pharmaceut Sci, Lab Analyt Pharmaceut Chem, B-4000 Liege, Belgium. Additional authors for this research include Y. Feng, X.H. Jin, X.X. Fan, J. Crommen and Z.J. Jiang (see also Biotechnology).
Keywords for this news article include: Biotechnology, Liege, Europe, Belgium, Therapy, Liposomes, Nanotechnology, Electrokinetics, Drug Delivery Systems, Emerging Technologies
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