Study Data from Massachusetts General Hospital Provide New Insights into Rheumatoid Arthritis (Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Autoimmune Diseases. According to news originating from Cambridge, Massachusetts, by NewsRx correspondents, research stated, "Rheumatoid arthritis (RA) is a chronic inflammatory immune disease causing the inflammation of synovial membrane and the articular cartilage destruction. In this work, hyaluronate gold nanoparticle/Tocilizumab (HA-AuNP/TCZ) complex was prepared for the treatment of RA."
Our news journalists obtained a quote from the research from Massachusetts General Hospital, "AuNP was used as a drug carrier with antiangiogenic effect. in is a humanized monoclonal antibody against the interleukin-6 (IL-6) receptor and used as an immunosuppressive drug by Interfering IL-6 in the pathogenesis of RA. HA is known to have cartilage-protective and lubricant effects. HA was modified with cystamine via reductive amination, which was reduced with dithiothreitol (DTT) to prepare end-group thiolated HA (HA-SH). AuNP was chemically modified with HA-SH and physically modified with T. The formation of HA-AuNP/TCZ complex was corroborated by UV-vis spectroscopy, dynamic light scattering (DLS), and transmission electron microscopy (TEM)."
According to the news editors, the research concluded: "The therapeutic effect of HA-AuNP/TCZ complex on RA was confirmed In collagen-induced arthritis (CIA) model mice by ELISA, histological, and Western blot analyses."
For more information on this research see: Hyaluronate-Gold Nanoparticle/Tocilizumab Complex for the Treatment of Rheumatoid Arthritis. ACS Nano, 2014;8(5):4790-4798. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
The news correspondents report that additional information may be obtained from H. Lee, Massachusetts General Hospital, Cambridge, MA 02139, United States. Additional authors for this research include M.Y. Lee, S.H. Bhang, B.S. Kim, Y.S. Kim, J.H. Ju, K.S. Kim and S.K. Hahn (see also Autoimmune Diseases).
Keywords for this news article include: Cambridge, Massachusetts, United States, Nanotechnology, Gold Nanoparticles, Autoimmune Diseases, Rheumatoid Arthritis, Emerging Technologies, North and Central America
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