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Study Data from G. Janer and Co-Authors Update Knowledge of Nanoparticles (Cell uptake and oral absorption of titanium dioxide nanoparticles)

July 1, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Nanoparticles. According to news reporting out of Terrassa, Spain, by NewsRx editors, research stated, "Large efforts are invested on the development of in vitro tests to evaluate nanomaterial (NM) toxicity. In order to assess the relevance of the adverse effects identified in in vitro toxicity tests a thorough understanding of the biokinetics of NMs is critical."

Our news journalists obtained a quote from the research, "We used different in vitro and in vivo test methods to evaluate cell uptake and oral absorption of titanium dioxide nanoparticles (TiO2 NPs). These NPs were readily uptaken by A549 cells (carcinomic human alveolar basal epithelial cells) in vitro. Such rapid uptake contrasted with a very low oral absorption in a differentiated Caco-2 monolayer system (human epithelial colorectal adenocarcinoma cells) and after oral gavage administration to rats. In this oral study, no significant increase in the levels of titanium was recorded by ICP-MS in any of the tissues evaluated (including among other: small intestine, Peyer's patches, mesenteric lymph nodes, liver, and spleen). No NPs were observed by TEM in sections of the small intestine, except for several particles in the cytoplasm of a cell from a Peyer's Patch area."

According to the news editors, the research concluded: "The observation of NPs in Peyer's Patch suggests that the Caco-2 monolayer system is likely to underestimate the potential for oral absorption of NPs and that the model could be improved by including M-cells in co-culture."

For more information on this research see: Cell uptake and oral absorption of titanium dioxide nanoparticles. Toxicology Letters, 2014;228(2):103-110. Toxicology Letters can be contacted at: Elsevier Ireland Ltd, Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland. (Elsevier -; Toxicology Letters -

Our news journalists report that additional information may be obtained by contacting G. Janer, LEITAT Technol Center, Terrassa 08225, Spain. Additional authors for this research include E.M. del Molino, E. Fernandez-Rosas, A. Fernandez and S. Vazquez-Campos (see also Nanoparticles).

Keywords for this news article include: Spain, Europe, Terrassa, Chemicals, Chemistry, Light Metals, Nanotechnology, Titanium Dioxide, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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