Study Data from Case Western Reserve University Update Knowledge of Fullerenes (Platinized Aligned Carbon Nanotube-Sheathed Carbon Fiber Microelectrodes for In Vivo Amperometric Monitoring of Oxygen)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Fullerenes. According to news reporting from Cleveland, Ohio, by NewsRx journalists, research stated, "The abnormal level of O-2 could disturb various neurochemical processes and even induce neural injury and brain dysfunction. In order to assess critical roles of O-2 in the neurochemical processes, it is essential to perform in vivo monitoring of the dynamic changes of O-2."
The news correspondents obtained a quote from the research from Case Western Reserve University, "In this study, we develop a new electrochemical method for selectively monitoring O-2 in vivo, using platinized vertically aligned carbon nanotube (VACNT)-sheathed carbon fibers (Pt/VACNT-CFs) as the electrodes. The VACNT-sheathed CFs (VACNT-CFs) are produced via the pyrolysis of iron phthalocyanine (FePc) on the surface of CFs, followed by electrochemical deposition of platinum nanoparticles to form Pt/VACNT-CFs. The resulting Pt/VACNT-CF microelectrodes exhibit fast overall kinetics for the O-2 reduction via a four-electron reduction process without the formation of toxic H2O2 intermediate. Consequently, effective and selective electrochemical methods are developed for the measurements of O2 in rat brain with the Pt/VACNT-CF microelectrodes, even in the presence of some species at their physiological levels, such as ascorbic acid, dopamine, uric acid, 5-hydroxytryptamine, and of the O-2 fluctuation in rat brain in the early stage of global cerebral ischemia/reperfusion, mild hyperoxia, and hypoxia induced by exposing the animal, for a short time, to O-2 and N-2 respectively, and hindfeet pinch. The use of VACNT-CF as the support for Pt effectively improves the stability of Pt, as compared with the bare CF support, while the FePc pyrolysis ensures the VACNT-CFs to be reproducibly produced."
According to the news reporters, the research concluded: "Thus, this study offers a novel and reliable strategy for preparing new microelectrodes for in vivo monitoring of O-2 in various physiological processes with a high sensitivity and selectivity."
For more information on this research see: Platinized Aligned Carbon Nanotube-Sheathed Carbon Fiber Microelectrodes for In Vivo Amperometric Monitoring of Oxygen. Analytical Chemistry, 2014;86(10):5017-5023. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)
Our news journalists report that additional information may be obtained by contacting L. Xiang, Case Western Reserve University, Dept. of Macromol Sci & Engn, Cleveland, OH 44106, United States. Additional authors for this research include P. Yu, M.N. Zhang, J. Hao, Y.X. Wang, L. Zhu, L.M. Dai and L.Q. Mao (see also Fullerenes).
Keywords for this news article include: Ohio, Cleveland, Chemistry, Fullerenes, United States, Electrochemical, Carbon Nanotubes, North and Central America
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