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Studies in the Area of Nanoparticles Reported from Fudan University (Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of...

July 1, 2014



Studies in the Area of Nanoparticles Reported from Fudan University (Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats)

By a News Reporter-Staff News Editor at Life Science Weekly -- Research findings on Nanoparticles are discussed in a new report. According to news reporting out of Shanghai, People's Republic of China, by NewsRx editors, research stated, "Endometriosis is defined as the presence of endometrial tissue outside the uterine, which may affect nearly 60% of women in reproductive age. Deep infiltrating endometriosis (DIE) defined as an endometriotic lesion penetrating into the retroperitoneal space or the wall of the pelvic organs to a depth of at least 5 mm represents the most diagnostic challenge."

Our news journalists obtained a quote from the research from Fudan University, "Herein, we reported the use of hyaluronic acid (HA)-modified magnetic iron oxide nanoparticles (HA-Fe3O4 NPs) for magnetic resonance (MR) imaging of endometriotic lesions in the rodent model. Sixteen endometriotic lesions were surgically induced in eight rats by autologous transplantation. Four weeks after lesion induction, three rats were scanned via MR imaging after tail vein injection of the HA-Fe3O4 NPs. Accordingly, the remaining five mice were sacrificed in the corresponding time points. The ectopic uterine tissues (EUTs) were confirmed by histological analysis. Quantification of Fe in the EUT was also performed by inductively coupled plasma-optical emission spectroscopy. Our results showed that by using the HA-Fe3O4 NPs, the EUTs were able to be visualized via T2-weighted MR imaging at 2 hours post injection, corroborating the Prussian blue staining results."

According to the news editors, the research concluded: "The developed HA-Fe3O4 NPs could be used as negative contrast agents for sensitively detecting endometriosis in a mouse model and may be applied for future hyperthermia treatment of endometriosis."

For more information on this research see: Hyaluronic acid-modified magnetic iron oxide nanoparticles for MR imaging of surgically induced endometriosis model in rats. Plos One, 2014;9(4):e94718. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

Our news journalists report that additional information may be obtained by contacting H. Zhang, Dept. of Radiology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai, People's Republic of China. Additional authors for this research include J. Li, W. Sun, Y. Hu, G. Zhang, M. Shen and X. Shi (see also Nanoparticles).

Keywords for this news article include: Asia, Shanghai, Nanotechnology, Emerging Technologies, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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