Studies from University of California Update Current Data on Gastroenterology (Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract)
By a News Reporter-Staff News Editor at Clinical Trials Week -- Researchers detail new data in Gastroenterology. According to news reporting originating in Los Angeles, California, by NewsRx journalists, research stated, "We have previously demonstrated that there is a relationship between the aspect ratio (AR) of CeO2 nanoparticles and in vitro hazard potential. CeO2 nanorods with AR >= 22 induced lysosomal damage and progressive effects on IL-1 beta production and cytotoxicity in the human myeloid cell line, THP-1."
The news reporters obtained a quote from the research from the University of California, "In order to determine whether this toxicological paradigm for long aspect ratio (LAR) CeO2 is also relevant in vivo, we performed comparative studies in the mouse lung and gastrointestinal tract (GIT) of zebrafish larvae. Although oropharyngeal aspiration could induce acute lung inflammation for CeO2 nanospheres and nanorods, only the nanorods with the highest AR ((5) induced significant IL-1 beta and TGF-beta 1 production In the bronchoalveolar lavage fluid at 21 days but did not induce pulmonary fibrosis. However, after a longer duration (44 days) exposure to 4 mg/kg of the C5 nanorods, more collagen production was seen with CeO2 nanorods vs nanospheres after correcting for Ce lung burden. Using an oral-exposure model In zebrafish larvae, we demonstrated that C5 nanorods also induced significant growth inhibition, a decrease in body weight, and delayed vertebral calcification. In contrast, CeO2 nanospheres and shorter nanorods had no effect. Histological and transmission electron microscopy analyses showed that the key injury mechanism of C5 was in the epithelial lining of the GIT, which demonstrated blunted microvilli and compromised digestive function."
According to the news reporters, the research concluded: "All considered, these data demonstrate that, similar to cellular studies, LAR CeO2 nanorods exhibit more toxicity in the lung and GIT, which could be relevant to inhalation and environmental hazard potential."
For more information on this research see: Aspect Ratio Plays a Role in the Hazard Potential of CeO2 Nanoparticles in Mouse Lung and Zebrafish Gastrointestinal Tract. ACS Nano, 2014;8(5):4450-4464. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting S.J. Lin, University of California, Dept. of Chem & Biochem, Los Angeles, CA 90095, United States. Additional authors for this research include X. Wang, Z.X. Ji, C.H. Chang, Y. Dong, H. Meng, Y.P. Liao, M.Y. Wang, T.B. Song, S. Kohan, T. Xia, J.I. Zink, S. Lin and A.E. Nel (see also Gastroenterology).
Keywords for this news article include: Nanorod, California, Nanosphere, Los Angeles, Nanoparticle, United States, Nanotechnology, Gastroenterology, Emerging Technologies, North and Central America
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