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Studies from University Hospital Have Provided New Information about Dementia (Systematic Comparison of the Performance of Integrated Whole-Body...

June 30, 2014



Studies from University Hospital Have Provided New Information about Dementia (Systematic Comparison of the Performance of Integrated Whole-Body PET/MR Imaging to Conventional PET/CT for F-18-FDG Brain Imaging in Patients Examined for Suspected ...)

By a News Reporter-Staff News Editor at Clinical Trials Week -- Current study results on Dementia and Mental Illness have been published. According to news reporting originating from Cologne, Germany, by NewsRx correspondents, research stated, "Technologic specifications of recently introduced integrated PET/MR instrumentation, such as MR-based attenuation correction, may particularly affect brain imaging procedures. To evaluate the qualitative performance of PET/MR in clinical neuroimaging, we systematically compared results obtained with integrated PET/MR with conventional PET/CT in the same patients examined for assessment of cognitive impairment."

Our news editors obtained a quote from the research from University Hospital, "Thirty patients underwent a single-injection (F-18-FDG), dual-imaging protocol including PET/CT and integrated PET/MR imaging in randomized order. Attenuation and scatter correction were performed using low-dose CT for the PET/CT and segmented Dixon MR imaging data for the PET/MR. Differences between PET/MR and PET/CT were assessed via region-of-interest (ROI) based and voxel-based statistical group comparison. Analyses involved attenuation-corrected (AC) and non attenuation-corrected (NAC) data. Individual PET/MR and PET/CT datasets were compared versus a predefined independent control population, using 3-dimensional stereotactic surface projections. Generally, lower measured PET signal values were obtained throughout the brain in ROI-based quantification of the PET signal for PET/MR as compared with PET/CT in AC and NAC data, independently of the scan order. After elimination of global effects, voxel-based and ROI-based group comparison still revealed significantly lower relative tracer signal in PET/MR images in frontoparietal portions of the neocortex but significantly higher relative signal in subcortical and basal regions of the brain than the corresponding PET/CT images of the AC data. In the corresponding NAC images, the discrepancies in frontoparietal portions of the neocortex were diminished, but the subcortical overestimation of tracer intensity by PET/MR persisted. Considerable region-dependent differences were observed between brain imaging data acquired on the PET/MR, compared with corresponding PET/CT images, in patients evaluated for neurodegenerative disorders. These findings may only in part be explained by inconsistencies in the attenuation-correction procedures. The observed differences may interfere with semiquantitative evaluation and with individual qualitative clinical assessment and they need to be considered, for example, for clinical trials."

According to the news editors, the research concluded: "Improved attenuation-correction algorithms and a PET/MR-specific healthy control database are recommended for reliable and consistent application of PET/MR for clinical neuroimaging."

For more information on this research see: Systematic Comparison of the Performance of Integrated Whole-Body PET/MR Imaging to Conventional PET/CT for F-18-FDG Brain Imaging in Patients Examined for Suspected Dementia. Journal of Nuclear Medicine, 2014;55(6):923-931. Journal of Nuclear Medicine can be contacted at: Soc Nuclear Medicine Inc, 1850 Samuel Morse Dr, Reston, VA 20190-5316, USA (see also Dementia and Mental Illness).

The news editors report that additional information may be obtained by contacting S. Hitz, Univ Hosp Cologne, Dept. of Nucl Med, Cologne, Germany. Additional authors for this research include C. Habekost, S. Furst, G. Delso, S. Forster, S. Ziegler, S.G. Nekolla, M. Souvatzoglou, A.J. Beer, T. Grimmer, M. Eiber, M. Schwaiger and A. Drzezga.

Keywords for this news article include: Europe, Cologne, Germany, Neuroimaging, Brain Diseases, Dementia and Mental Illness, Central Nervous System Diseases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Clinical Trials Week


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