Studies from National Nanotechnology Laboratory Have Provided New Data on Nanocubes (Heat-Generating Iron Oxide Nanocubes: Subtle "Destructurators" of the Tumoral Microenvironment)
By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Nanocubes is the subject of a report. According to news reporting originating in Lecce, Italy, by NewsRx journalists, research stated, "Several studies propose nanoparticles for tumor treatment, yet little is known about the fate of nanoparticles and intimate interactions with the heterogeneous and ever-evolving tumor environment. The latter, rich in extracellular matrix, is responsible for poor penetration of therapeutics and represents a paramount Issue in cancer therapy."
The news reporters obtained a quote from the research from National Nanotechnology Laboratory, "Hence new strategies start aiming to modulate the neoplastic stroma. From this perspective, we assessed the efficacy of 19 nm PEG-coated iron oxide nanocubes with optimized magnetic properties to mediate mild tumor magnetic hyperthermia treatment. After injection of a low dose of nanocubes (700 mu g of iron) into epidermoid carcinoma xenografts in mice, we monitored the effect of heating nanocubes on tumor environment. In comparison with the long-term fate after intravenous administration, we investigated spatiotemporal patterns of nanocube distribution, evaluated the evolution of cubes magnetic properties, and examined nanoparticle clearance and degradation processes. While inside tumors nanocubes retained their magnetic properties and heating capacity throughout the treatment due to a mainly interstitial extracellular location, the particles became inefficient heaters after cell internalization and transfer to spleen and liver. Our multiscale analysis reveals that collagen-rich tumor extracellular matrix confines the majority of nanocubes. However, nanocube-mediated hyperthermia has the potential to 'destructure' this matrix and improve nanoparticle and drug penetration Into neoplastic tissue."
According to the news reporters, the research concluded: "This study provides insight into dynamic interactions between nanoparticles and tumor components under physical stimulation and suggests that nanoparticle-mediated hyperthermia could be used to locally modify tumor stroma and thus improve drug penetration."
For more information on this research see: Heat-Generating Iron Oxide Nanocubes: Subtle "Destructurators" of the Tumoral Microenvironment. ACS Nano, 2014;8(5):4268-4283. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting J. Kolosnjaj-Tabi, CNR NANO, Natl Nanotechnol Lab, I-73100 Lecce, Italy. Additional authors for this research include R. Di Corato, L. Lartigue, I. Marangon, P. Guardia, A.K.A. Silva, N. Luciani, O. Clement, P. Flaud, J.V. Singh, P. Decuzzi, T. Pellegrino, C. Wilhelm and F. Gazeau (see also Nanocubes).
Keywords for this news article include: Lecce, Italy, Europe, Nanocubes, Nanoparticle, Nanotechnology, Emerging Technologies
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