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Studies Conducted at University of Southern California on Tissue Engineering Recently Reported (Functionalization of scaffolds with chimeric...

July 2, 2014

Studies Conducted at University of Southern California on Tissue Engineering Recently Reported (Functionalization of scaffolds with chimeric anti-BMP-2 monoclonal antibodies for osseous regeneration)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Biomedicine and Biomedical Engineering have been published. According to news originating from Los Angeles, California, by NewsRx correspondents, research stated, "Recent studies have demonstrated the ability of murine anti-BMP-2 monoclonal antibodies (mAb) immobilized on an absorbable collagen sponge (ACS) to mediate de novo bone formation, a process termed antibody-mediated osseous regeneration (AMOR). The objectives of this study were to assess the efficacy of a newly generated chimeric anti-BMP-2 mAb in mediating AMOR, as well as to evaluate the suitability of different biomaterials as scaffolds to participate in AMOR."

Our news journalists obtained a quote from the research from the University of Southern California, "Chimeric anti-BMP-2 mAb was immobilized on 4 biomaterials, namely, titanium microbeads (Ti), alginate hydrogel, macroporous biphasic calcium phosphate (MBCP) and ACS, followed by surgical implantation into rat critical-size calvarial defects. Animals were sacrificed after 8 weeks and the degree of bone fill was assessed using micro-CT and histomorphometry. Results demonstrated local persistence of chimeric anti-BMP-2 mAb up to 8 weeks, as well as significant de novo bone regeneration in sites implanted with chimeric anti-BMP-2 antibody immobilized on each of the 4 scaffolds. Ti and MBCP showed the highest volume of bone regeneration, presumably due to their resistance to compression. Alginate and ACS also mediated de novo bone formation, though significant volumetric shrinkage was noted. In vitro assays demonstrated cross-reactivity of chimeric anti-BMP-2 mAb with BMP-4 and BMP-7. Immune complex of anti-BMP-2 mAb with BMP-2 induced osteogenic differentiation of C2C12 cells in vitro, involving expression of RUNX2 and phosphorylation of Smad1."

According to the news editors, the research concluded: "The present data demonstrated the ability of chimeric anti-BMP-2 mAb to functionalize different biomaterial with varying characteristics to mediate osteogenesis."

For more information on this research see: Functionalization of scaffolds with chimeric anti-BMP-2 monoclonal antibodies for osseous regeneration. Biomaterials, 2013;34(38):10191-8. (Elsevier -; Biomaterials -

The news correspondents report that additional information may be obtained from S. Ansari, Ostrow School of Dentistry, University of Southern California, Los Angeles, CA, United States. Additional authors for this research include A. Moshaverinia, S.H. Pi, A. Han, A.I. Abdelhamid and H.H Zadeh (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, California, Immunology, Los Angeles, United States, Bone Research, Bioengineering, Blood Proteins, Immunoglobulins, Serum Globulins, Monoclonal Antibodies, North and Central America.

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Source: Biotech Week

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