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Studies Conducted at Rural Development Administration on Nanoparticles Recently Reported (Quantitation of Oxidative Stress Gene Expression in MCF-7...

July 4, 2014



Studies Conducted at Rural Development Administration on Nanoparticles Recently Reported (Quantitation of Oxidative Stress Gene Expression in MCF-7 Human Cell Lines Treated with Water-Dispersible CuO Nanoparticles)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Nanoparticles. According to news reporting originating from Suwon, South Korea, by NewsRx correspondents, research stated, "The objective of this study was to assess the cytotoxicity of water-dispersible CuO nanoparticles by quantifying the reactive oxygen species (ROS)-related genes (glutathione S-transferase (GST) and catalase) using real-time polymerase chain reaction (RT-PCR). Monodisperse CuO nanoparticles of 14 nm in size were used."

Our news editors obtained a quote from the research from Rural Development Administration, "Cytotoxicity of CuO nanoparticles was evaluated under in vitro condition at different concentrations (10, 50, and 100 mu g/ml) and incubation times (12, 24, and 48 h) with human cancer cell lines (breast cancer epithelial cells). The genetic level cytotoxic screening produced consistent results showing that GST and catalase ROS gene expression was maximized in 24 h incubation at 100 mu g/ml concentration of CuO nanoparticles."

According to the news editors, the research concluded: "However, the cytotoxicity of water-dispersible CuO nanoparticle was not significant compared with control experiments, demonstrating its high potential in the application of nanomedicines for a diagnostic and therapeutic tool."

For more information on this research see: Quantitation of Oxidative Stress Gene Expression in MCF-7 Human Cell Lines Treated with Water-Dispersible CuO Nanoparticles. Applied Biochemistry and Biotechnology, 2014;173(3):731-740. Applied Biochemistry and Biotechnology can be contacted at: Humana Press Inc, 999 Riverview Drive Suite 208, Totowa, NJ 07512, USA. (Springer - www.springer.com; Applied Biochemistry and Biotechnology - www.springerlink.com/content/0273-2289/)

The news editors report that additional information may be obtained by contacting R.S. Kumaran, Rural Dev Adm, Urban Agr Res Div, Natl Inst Hort & Herbal Sci, Suwon 441440, South Korea. Additional authors for this research include Y.K. Choi, H.J. Kim and K.J. Kim (see also Nanoparticles).

Keywords for this news article include: Asia, Suwon, Catalase, Enzymology, South Korea, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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