Researchers from University of Western Ontario Detail Findings in Bacterial Infections (Characterization of anionic and cationic functionalized bacterial cellulose nanofibres for controlled release applications)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Fresh data on Bacterial Infections are presented in a new report. According to news reporting originating in London, Canada, by NewsRx journalists, research stated, "Bacterial cellulose (BC) is a biocompatible biopolymer synthesized by Gluconacetobacter xylinus. In this study, BC was oxidized and aminated to produce hydrogels for biomedical applications, and the products were characterized."
The news reporters obtained a quote from the research from the University of Western Ontario, "A carboxyl (pK(a) of 3.9 +/- A 0.1) content of 1.13 +/- A 0.02 mmol/g was obtained with the TEMPO-catalyzed oxidation. Epichlorohydrin-mediated amination introduced amine groups (pK(a) of 11.0 +/- A 0.1) up to 1.74 +/- A 0.06 mmol/g. The oxidation of BC caused a decrease in its zeta-potential to -103 +/- A 6 mV, and amination increased the zeta-potential to -4 +/- A 6 mV. The fibre diameter decreased after both reactions. The high absolute value of the zeta-potential for oxidized BC led to superior colloidal stability in water, and a 390 % increase in water retention. The oxidized BC hydrogel was also found to increase in water retention fivefold from pH 1 to 7, making it a smart hydrogel."
According to the news reporters, the research concluded: "The cationic and anionic BC hydrogels described here could be used for several biomedical applications, including self-assembling drug delivery devices."
For more information on this research see: Characterization of anionic and cationic functionalized bacterial cellulose nanofibres for controlled release applications. Cellulose, 2014;21(3):1529-1540. Cellulose can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Cellulose - www.springerlink.com/content/0969-0239/)
Our news correspondents report that additional information may be obtained by contacting M. Spaic, University of Western Ontario, Dept. of Chem & Biochem Engn, London, ON N6A 5B9, Canada. Additional authors for this research include D.P. Small, J.R. Cook and W.K. Wan (see also Bacterial Infections).
Keywords for this news article include: London, Canada, Ontario, Nanofibre, Nanotechnology, Controlled Release, Emerging Technologies, North and Central America, Bacterial Infections and Mycoses
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