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Researchers from Catholic University Describe Findings in Peptides and Proteins (Identification of multifunctional peptides from human milk)

July 1, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Peptides and Proteins. According to news reporting originating in Brasilia, Brazil, by NewsRx journalists, research stated, "Pharmaceutical industries have renewed interest in screening multifunctional bioactive peptides as a marketable product in health care applications. In this context, several animal and plant peptides with potential bioactivity have been reported."

The news reporters obtained a quote from the research from Catholic University, "Milk proteins and peptides have received much attention as a source of health-enhancing components to be incorporated into nutraceuticals and functional foods. By using this source, 24 peptides have been fractionated and purified from human milk using RP-HPLC. Multifunctional roles including antimicrobial, antioxidant and growth stimulating activity have been evaluated in all 24 fractions. Nevertheless, only four fractions show multiple combined activities among them. Using a proteomic approach, two of these four peptides have been identified as lactoferrin derived peptide and kappa casein short chain peptide. Lactoferrin derived peptide (f8) is arginine-rich and kappa casein derived (f12) peptide is proline-rich. Both peptides (f8 and f12) showed antimicrobial activities against both Gram-positive and Gram-negative bacteria. Fraction 8 (f8) exhibits growth stimulating activity in 3T3 cell line and fl2 shows higher free radical scavenging activity in comparison to other fractions. Finally, both peptides were in silico evaluated and some insights into their mechanism of action were provided."

According to the news reporters, the research concluded: "Thus, results indicate that these identified peptides have multiple biological activities which are valuable for the quick development of the neonate and may be considered as potential biotechnological products for nutraceutical industry."

For more information on this research see: Identification of multifunctional peptides from human milk. Peptides, 2014;56():84-93. Peptides can be contacted at: Elsevier Science Inc, 360 Park Ave South, New York, NY 10010-1710, USA. (Elsevier -; Peptides -

Our news correspondents report that additional information may be obtained by contacting S.M. Mandal, Pos Grad Ciencias Genom & Biotecnol Univ Catolica, Center Anal Proteom & Bioquim, Brasilia, DF, Brazil. Additional authors for this research include R. Bharti, W.F. Porto, S.S. Gauri, M. Mandal, O.L. Franco and A.K. Ghosh (see also Peptides and Proteins).

Keywords for this news article include: Brazil, Brasilia, Amino Acids, South America, Peptides and Proteins

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Source: Life Science Weekly

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