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Researchers at University of Miami Report Findings in Biosensing (Optical ATP biosensor for extracellular ATP measurement)

July 2, 2014

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Biosensing have been published. According to news reporting out of Coral Gables, Florida, by NewsRx editors, research stated, "Extracellular Adenosine-5'-triphosphate (ATP) is an important multi-functional molecule which can mediate numerous physiological activities by activating purinergic P2 receptors. The objective of this study was to develop a novel optical ATP sensor for in-situ extracellular ATP measurement in biological tissues."

Our news journalists obtained a quote from the research from the University of Miami, "The optical ATP sensor was made by applying two layers of sol-gel coating to the end of an optical fiber probe end. The first layer contained ruthenium complex for sensing changes in oxygen concentration which resulted from oxidation of ATP by glycerol kinase and glycerol 3-phosphate oxidase entrapped in the second layer. It was demonstrated that the optical ATP sensor was capable of detecting ATP concentration at a broad range of 10(-3)mM to 1.5mM.A compensation method was established to enable the optical sensor to determine ATP concentration at different oxygen levels. This study also demonstrated the capability of ATP sensor to measure extracellular ATP content in biological tissues (i.e., porcine intervertebral disc). In addition, it was shown that the optical ATP sensor was not affected by pH and derivatives of extracellular ATP."

According to the news editors, the research concluded: "Therefore, the newly developed optical ATP sensor is a good option for in-situ extracellular ATP measurement."

For more information on this research see: Optical ATP biosensor for extracellular ATP measurement. Biosensors & Bioelectronics, 2013;43():355-61. (Elsevier -; Biosensors & Bioelectronics -

Our news journalists report that additional information may be obtained by contacting C. Wang, Dept. of Biomedical Engineering, University of Miami, Coral Gables, FL 33146, United States. Additional authors for this research include C.Y. Huang and W.C Lin (see also Biosensing).

Keywords for this news article include: Florida, Biosensing, Coral Gables, United States, Bioengineering, Bionanotechnology, Nanobiotechnology, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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