News Column

Reports Outline Connective Tissue Cells Findings from Yale University (Engineering Cellular Response Using Nanopatterned Bulk Metallic Glass)

July 1, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Connective Tissue Cells have been presented. According to news originating from New Haven, Connecticut, by NewsRx correspondents, research stated, "Nanopatterning of biomaterials is rapidly emerging as a tool to engineer cell function. Bulk metallic glasses (BMGs), a class of biocompatible materials, are uniquely suited to study nanopattern - cell interactions as they allow for versatile fabrication of nanopatterns through thermoplastic forming."

Our news journalists obtained a quote from the research from Yale University, "Work presented here employs nanopatterned BMG substrates to explore detection of nanopattern feature sizes by various cell types, including cells that are associated with foreign body response, pathology, and tissue repair. Fibroblasts decreased in cell area as the nanopattern feature size increased, and fibroblasts could detect nanopatterns as small as 55 nm in size. Macrophages failed to detect nanopatterns of 150 nm or smaller In size, but responded to a feature size of 200 nm, resulting in larger and more elongated cell morphology. Endothelial cells responded to nanopatterns of 100 nm or larger in size by a significant decrease in cell size and elongation. On the basis of these observations, nondimensional analysis was employed to correlate cellular morphology and substrate nanotopography. Analysis of the molecular pathways that induce cytoskeletal remodeling, in conjunction with quantifying cell traction forces with nanoscale precision using a unique FIB-SEM technique, enabled the characterization of underlying blomechanical cues. Nanopatterns altered serum protein adsorption and effective substrate stiffness, leading to changes in focal adhesion density and compromised activation of Rho-A GTPase in fibroblasts. As a consequence, cells displayed restricted cell spreading and decreased collagen production."

According to the news editors, the research concluded: "These observations suggest that topography on the nanoscale can be designed to engineer cellular responses to biomaterials."

For more information on this research see: Engineering Cellular Response Using Nanopatterned Bulk Metallic Glass. ACS Nano, 2014;8(5):4366-4375. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; ACS Nano -

The news correspondents report that additional information may be obtained from J. Padmanabhan, Yale University, Dept. of Pathol, New Haven, CT 06520, United States. Additional authors for this research include E.R. Kinser, M.A. Stalter, C. Duncan-Lewis, J.L. Balestrini, A.J. Sawyer, J. Schroers and T.R. Kyriakides (see also Connective Tissue Cells).

Keywords for this news article include: New Haven, Nanoscale, Connecticut, Engineering, Fibroblasts, United States, Nanotechnology, Emerging Technologies, Connective Tissue Cells, North and Central America

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Source: Life Science Weekly

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