News Column

Reports on Nanoparticles Findings from Johannes Gutenberg-University Provide New Insights (Molybdenum Trioxide Nanoparticles with Intrinsic Sulfite...

July 1, 2014

Reports on Nanoparticles Findings from Johannes Gutenberg-University Provide New Insights (Molybdenum Trioxide Nanoparticles with Intrinsic Sulfite Oxidase Activity)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Nanoparticles have been published. According to news reporting out of Mainz, Germany, by NewsRx editors, research stated, "Sulfite oxidase is a mitochondria-located molybdenum-containing enzyme catalyzing the oxidation of sulfite to sulfate in the amino acid and lipid metabolism."

Our news journalists obtained a quote from the research from Johannes Gutenberg-University, "Therefore, it plays a major role in detoxification processes, where defects in the enzyme cause a severe infant disease leading to early death with no efficient or cost-effective therapy in sight. Here we report that molybdenum trioxide (MoO3) nanoparticles display an intrinsic biomimetic sulfite oxidase activity under physiological conditions, and, functionalized with a customized bifunctional ligand containing dopamine as anchor group and triphenylphosphonium ion as targeting agent, they selectively target the mitochondria while being highly dispersible in aqueous solutions."

According to the news editors, the research concluded: "Chemically induced sulfite oxidase knockdown cells treated with MoO3 nanoparticles recovered their sulfite oxidase activity in vitro, which makes MoO3 nanoparticles a potential therapeutic for sulfite oxidase deficiency and opens new avenues for cost-effective therapies for gene-induced deficiencies."

For more information on this research see: Molybdenum Trioxide Nanoparticles with Intrinsic Sulfite Oxidase Activity. ACS Nano, 2014;8(5):5182-5189. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; ACS Nano -

Our news journalists report that additional information may be obtained by contacting R. Ragg, Johannes Gutenberg Univ Mainz, Medical Klin & Poliklin, Univ Med, D-55131 Mainz, Germany. Additional authors for this research include F. Natalio, M.N. Tahir, H. Janssen, A. Kashyap, D. Strand, S. Strand and W. Tremel (see also Nanoparticles).

Keywords for this news article include: Mainz, Europe, Germany, Oxidase, Chemicals, Chemistry, Nanotechnology, Molybdenum Trioxide, Transition Elements, Emerging Technologies, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

For more stories covering the world of technology, please see HispanicBusiness' Tech Channel

Source: Life Science Weekly

Story Tools Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters