News Column

Reports from Duke University Add New Data to Findings in DNA Research (Molecular sentinel-on-chip for SERS-based biosensing)

July 1, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in DNA Research. According to news reporting originating from Durham, North Carolina, by NewsRx correspondents, research stated, "The development of DNA detection techniques on large-area plasmonics-active platforms is critical for many medical applications such as high-throughput screening, medical diagnosis and systems biology research. Here, we report for the first time a unique 'molecular sentinel-on-chip' (MSC) technology for surface-enhanced Raman scattering (SERS)-based DNA detection."

Our news editors obtained a quote from the research from Duke University, "This unique approach allows label-free detection of DNA molecules on chips developed on a wafer scale using large area nanofabrication methodologies. To develop plasmonics-active biosensing platforms in a repeatable and reproducible manner, we employed a combination of deep UV lithography, atomic layer deposition, and metal deposition to fabricate triangular-shaped nanowire (TSNW) arrays having controlled sub-10 nm gap nanostructures over an entire 6 inch wafer."

According to the news editors, the research concluded: "The detection of a DNA sequence of the Ki-67 gene, a critical breast cancer biomarker, on the TSNW substrate illustrates the usefulness and potential of the MSC technology as a novel SERS-based DNA detection method."

For more information on this research see: Molecular sentinel-on-chip for SERS-based biosensing. Physical Chemistry Chemical Physics, 2013;15(16):6008-15. (Royal Society of Chemistry - www.rsc.org/; Physical Chemistry Chemical Physics - pubs.rsc.org/en/journals/journalissues/cp)

The news editors report that additional information may be obtained by contacting H.N. Wang, Fitzpatrick Institute for Photonics, Duke University, Durham, NC, United States. Additional authors for this research include A. Dhawan, Y. Du, D. Batchelor, D.N. Leonard, V. Misra and T. Vo-Dinh (see also DNA Research).

Keywords for this news article include: Durham, Technology, DNA Research, United States, North Carolina, North and Central America.

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Source: Life Science Weekly