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Reports from Albanova University Highlight Recent Findings in Chemical Biology (Recent achievements in developing the biocatalytic toolbox for chiral...

July 1, 2014



Reports from Albanova University Highlight Recent Findings in Chemical Biology (Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis)

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Chemical Biology have been presented. According to news originating from Stockholm, Sweden, by NewsRx correspondents, research stated, "Novel enzyme activities and chemoenzymatic reaction concepts have considerably expanded the biocatalytic toolbox for chiral amine synthesis. Creating new activities or extending the scope of existing enzymes by protein engineering is a common trend in biocatalysis and in chiral amine synthesis specifically."

Our news journalists obtained a quote from the research from Albanova University, "For instance, an amine dehydrogenase that allows for the direct asymmetric amination of ketones with ammonia was created by mutagenesis of an L-amino acid dehydrogenase. Another trend in chiral amine chemistry is the development of strategies allowing for the synthesis of secondary amines. For example the smart choice of substrates for amine transaminases provided access to secondary amines by chemoenzymatic reactions. Furthermore novel biocatalysts for the synthesis of secondary amines such as imine reductases and Pictet-Spenglerases have been identified and applied. Recent examples showed that the biocatalytic amine synthesis is emerging from simple model reactions towards industrial scale preparation of pharmaceutical relevant substances, for instance, as shown in the synthesis of a Janus kinase 2 inhibitor using an amine transaminase."

According to the news editors, the research concluded: "A comparison of important process parameters such as turnover number and space-time yield demonstrates that biocatalytic strategies for asymmetric reductive amination are maturing and can already compete with established chemical methods."

For more information on this research see: Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis. Current Opinion in Chemical Biology, 2014;19():180-192. Current Opinion in Chemical Biology can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Current Opinion in Chemical Biology - www.elsevier.com/wps/product/cws_home/601299)

The news correspondents report that additional information may be obtained from H. Kohls, AlbaNova Univ Center, KTH Royal Inst Technol, Div Ind Biotechnol, S-10691 Stockholm, Sweden. Additional authors for this research include F. Steffen-Munsberg and M. Hohne (see also Chemical Biology).

Keywords for this news article include: Sweden, Europe, Stockholm, Dehydrogenase, Chemical Biology, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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