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Recent Studies from Rice University Add New Data to Biomacromolecules (Self-assembling multidomain peptide fibers with aromatic cores)

July 1, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Life Science Research. According to news reporting originating from Houston, Texas, by NewsRx correspondents, research stated, "Self-assembling multidomain peptides have been shown to have desirable properties, such as the ability to form hydrogels that rapidly recover following shear-thinning and the potential to be tailored by amino acid selection to vary their elasticity and encapsulate and deliver proteins and cells. Here we describe the effects of substitution of aliphatic hydrophobic amino acids in the central domain of the peptide for the aromatic amino acids phenylalanine, tyrosine, and tryptophan."

Our news editors obtained a quote from the research from Rice University, "While the basic nanofibrous morphology is retained in all cases, selection of the particular core residues results in switching from antiparallel hydrogen bonding to parallel hydrogen bonding in addition to changes in nanofiber morphology and in hydrogel rheological properties. Peptide nanofiber assemblies are investigated by circular dichroism polarimetry, infrared spectroscopy, atomic force microscopy, transmission and scanning electron microscopy, oscillatory rheology, and molecular dynamics simulations."

According to the news editors, the research concluded: "Results from this study will aid in designing next generation cell scaffolding materials."

For more information on this research see: Self-assembling multidomain peptide fibers with aromatic cores. Biomacromolecules, 2013;14(5):1370-8. (American Chemical Society -; Biomacromolecules -

The news editors report that additional information may be obtained by contacting E.L. Bakota, Dept. of Chemistry, Rice University, 6100 South Main Street, Houston, Texas 77005, United States. Additional authors for this research include O. Sensoy, B. Ozgur, M. Sayar and J.D Hartgerink (see also Life Science Research).

Keywords for this news article include: Texas, Houston, United States, Life Science Research, North and Central America.

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Source: Life Science Weekly

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