Recent Findings from Center for Nanoscience and Nanotechnology Provides New Insights into Gene Therapy (Molecular Recognition Enables Nanosubstrate-Mediated Delivery of Gene-Encapsulated Nanoparticles with High Efficiency)
By a News Reporter-Staff News Editor at Gene Therapy Weekly -- New research on Biotechnology is the subject of a report. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Substrate-mediated gene delivery is a promising method due to its unique ability to preconcentrate exogenous genes onto designated substrates, However, many challenges remain to enable continuous and multiround delivery of the gene using the same substrates without depositing payloads and Immobilizing cells in each round of delivery. Herein we introduce a gene delivery system, nanosubstrate-mediated delivery (NSMD) platform, based on two functional components with nanoscale features, including (1) DNA subset of SNPs, supramolecular nanoparticle (SNP) vectors for gene encapsulation, and (2) Ad-SiNWS, adamantane (Ad)-grafted silicon nanowire substrates."
The news correspondents obtained a quote from the research from Center for Nanoscience and Nanotechnology, "The multivalent molecular recognition between the Ad motifs on Ad-SiNWS and the beta-cyclodextrin (CD) motifs on DNA subset of SNPs leads to dynamic assembly and local enrichment of DNA subset of SNPs from the surrounding medium onto Ad-SiNWS. Subsequently, once cells settled on the substrate, DNA subset of SNPs enriched on Ad-SiNWS were introduced through the cell membranes by Intimate contact with individual nanowires on Ad-SiNWS, resulting in a highly efficient delivery of exogenous genes. Most importantly, sequential delivery of multiple batches of exogenous genes on the same batch cells settled on Ad-SiNWS was realized by sequential additions of the corresponding DNA subset of SNPs with equivalent efficiency. Moreover, using the NSMD platform in vivo, cells recruited on subcutaneously transplanted Ad-SiNWS were also efficiently transfected with exogenous genes loaded into SNPs, validating the in vivo feasibility of this system."
According to the news reporters, the research concluded: "We believe that this nanosubstrate-mediated delivery platform will provide a superior system for in vitro and in vivo gene delivery and can be further used for the encapsulation and delivery of other biomolecules."
For more information on this research see: Molecular Recognition Enables Nanosubstrate-Mediated Delivery of Gene-Encapsulated Nanoparticles with High Efficiency. ACS Nano, 2014;8(5):4621-4629. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; ACS Nano - www.pubs.acs.org/journal/ancac3)
Our news journalists report that additional information may be obtained by contacting J.L. Peng, Natl Center Nanosci & Nanotechnol, Beijing 100190, People's Republic of China. Additional authors for this research include M.A. Garcia, J.S. Choi, L.B. Zhao, K.J. Chen, J.R. Bernstein, P. Peyda, Y.S. Hsiao, K.W. Liu, W.Y. Lin, A.D. Pyle, H. Wang, S. Hou and H.R. Tseng (see also Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Beijing, DNA Research, Gene Therapy, Nanoparticle, Bioengineering, Nanotechnology, Emerging Technologies, Molecular Recognition, People's Republic of China
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