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New Tissue Engineering Findings Has Been Reported by Investigators at Duke University (Tissue-engineered cartilage with inducible and tunable...

July 3, 2014

New Tissue Engineering Findings Has Been Reported by Investigators at Duke University (Tissue-engineered cartilage with inducible and tunable immunomodulatory properties)

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Current study results on Biomedicine and Biomedical Engineering have been published. According to news reporting out of Durham, North Carolina, by NewsRx editors, research stated, "The pathogenesis of osteoarthritis is mediated in part by inflammatory cytokines including interleukin-1 (IL-1), which promote degradation of articular cartilage and prevent human mesenchymal stem cell (MSC) chondrogenesis. In this study, we combined gene therapy and functional tissue engineering to develop engineered cartilage with immunomodulatory properties that allow chondrogenesis in the presence of pathologic levels of IL-1 by inducing overexpression of IL-1 receptor antagonist (IL-1Ra) in MSCs via scaffold-mediated lentiviral gene delivery."

Our news journalists obtained a quote from the research from Duke University, "A doxycycline-inducible vector was used to transduce MSCs in monolayer or within 3D woven PCL scaffolds to enable tunable IL-1Ra production. In the presence of IL-1, IL-1Ra-expressing engineered cartilage produced cartilage-specific extracellular matrix, while resisting IL-1-induced upregulation of matrix metalloproteinases and maintaining mechanical properties similar to native articular cartilage."

According to the news editors, the research concluded: "The ability of functional engineered cartilage to deliver tunable anti-inflammatory cytokines to the joint may enhance the long-term success of therapies for cartilage injuries or osteoarthritis."

For more information on this research see: Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Biomaterials, 2014;35(22):5921-5931. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biomaterials -

Our news journalists report that additional information may be obtained by contacting K.A. Glass, Duke University, Medical Center, Dept. of Cell Biol, Durham, NC 27710, United States. Additional authors for this research include J.M. Link, J.M. Brunger, F.T. Moutos, C.A. Gersbach and F. Guilak (see also Biomedicine and Biomedical Engineering).

Keywords for this news article include: Tissue Engineering, Biomedicine and Biomedical Engineering, Durham, United States, North Carolina, Bioengineering, North and Central America

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Source: Gene Therapy Weekly

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