New Oligopeptides Study Results Reported from National Research Council (Interaction with a Gold Surface Reshapes the Free Energy Landscape of Alanine Dipeptide)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators discuss new findings in Peptides. According to news reporting originating in Modena, Italy, by NewsRx journalists, research stated, "The adsorption of the alanine dipeptide onto a gold surface in aqueous conditions was explored by using molecular dynamics simulations. In particular, using Metadynamics, we reconstructed a three-dimensional free energy landscape to investigate the effect of the metal surface on such landscape."
The news reporters obtained a quote from the research from National Research Council, "The results show that the adsorption process is able to strongly modify the internal free energy surface of the molecule, even changing its qualitative appearance. The new free energy global minimum corresponds to elongated conformations of the biomolecule, arranged in preferred orientations with respect to the surface. Therefore, the surface-induced changes in the relative stability of the local free energy minima and in the free-energy barriers between them show that the entire conformational ensemble and the interconformer dynamics are also affected by the presence of the surface. The alanine dipeptide is the simplest molecule that exhibits the main features shown by larger peptides."
According to the news reporters, the research concluded: "Therefore, these findings provide a basis to rationalize, at the atomistic level, the effects of metal surfaces and nanoparticles on the structure and function of peptides and proteins, which is of paramount importance to engineer new systems for applications in bionanotechnology."
For more information on this research see: Interaction with a Gold Surface Reshapes the Free Energy Landscape of Alanine Dipeptide. Journal of Physical Chemistry C, 2014;118(21):11357-11364. Journal of Physical Chemistry C can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Physical Chemistry C - www.pubs.acs.org/journal/jpccck)
Our news correspondents report that additional information may be obtained by contacting L. Bellucci, CNR, Inst Nanosci, Center S3, I-41125 Modena, Italy (see also Peptides).
Keywords for this news article include: Italy, Modena, Europe, Dipeptides, Oligopeptides
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