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New Nanoparticles Data Have Been Reported by Researchers at University of Strathclyde (Confocal SERS Mapping of Glycan Expression for the...

June 30, 2014



New Nanoparticles Data Have Been Reported by Researchers at University of Strathclyde (Confocal SERS Mapping of Glycan Expression for the Identification of Cancerous Cells)

By a News Reporter-Staff News Editor at Clinical Trials Week -- New research on Nanoparticles is the subject of a report. According to news reporting originating from Glasgow, United Kingdom, by NewsRx correspondents, research stated, "Lectin-functionalized silver nanoparticles have been successfully designed for use as molecular imaging agents to investigate carbohydrate lectin interactions at the surface of mammalian cells, using surface-enhanced Raman scattering (SERS). Carbohydrate-lectin interactions are key to many cellular processes and are responsible for controlling an array of cellular interactions."

Our news editors obtained a quote from the research from the University of Strathclyde, "In this study, lectin-functionalized silver nanoparticles were used to detect the expression of carbohydrate species at the cellular interface. The carbohydrate-lectin interactions were demonstrated using three different lectin species for three distinct cell types. Due to the known difference between the expressions of glycans in cancerous versus noncancerous cells of the same origin, this approach has been expanded to study both cancerous and noncancerous prostate cells. This has been achieved via confocal SERS mapping of the expression of the key glycan, sialic acid, on the surface of each of these cell types. In achieving such discrimination, a novel method has been created by which glycan expression can be reproducibly monitored. Comparative studies were performed using both fluorescence and SERS. SERS provided an increased discrimination over fluorescence when analyzing cell subsets to discriminate between cancerous and noncancerous cells."

According to the news editors, the research concluded: "The success of this method means that it could be used to complement the current gold standard histopathological techniques."

For more information on this research see: Confocal SERS Mapping of Glycan Expression for the Identification of Cancerous Cells. Analytical Chemistry, 2014;86(10):4775-4782. Analytical Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Analytical Chemistry - www.pubs.acs.org/journal/ancham)

The news editors report that additional information may be obtained by contacting D. Craig, University of Strathclyde, WestCHEM, Center Mol Nanometrol, Glasgow G1 1XL, Lanark, United Kingdom. Additional authors for this research include S. McAughtrie, J. Simpson, C. McCraw, K. Faulds and D. Graham (see also Nanoparticles).

Keywords for this news article include: Europe, Glasgow, United Kingdom, Nanotechnology, Emerging Technologies

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Clinical Trials Week


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