News Column

New Intracellular Space Findings Reported from Princeton University (Mechanodelivery of nanoparticles to the cytoplasm of living cells)

July 1, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Intracellular Space. According to news reporting originating from Princeton, New Jersey, by NewsRx correspondents, research stated, "Nanotechnology has opened up the opportunity to probe, sense, and manipulate the chemical environment of biological systems with an unprecedented level of spatiotemporal control. A major obstacle to the full realization of these novel technologies is the lack of a general, robust, and simple method for the delivery of arbitrary nanostructures to the cytoplasm of intact live cells."

Our news editors obtained a quote from the research from Princeton University, "Here, we identify a new delivery modality, based on mechanical disruption of the plasma membrane, which efficiently mediates the delivery of nanoparticles to the cytoplasm of mammalian cells. We use two distinct execution modes, two adherent cell lines, and three sizes of semiconducting nanocrystals, or quantum dots, to demonstrate its applicability and effectiveness."

According to the news editors, the research concluded: "As the underlying mechanism is purely physical, we anticipate that such 'mechanodelivery' can be generalized to other modes of execution as well as to the cytoplasmic introduction of a structurally diverse array of functional nanomaterials."

For more information on this research see: Mechanodelivery of nanoparticles to the cytoplasm of living cells. Nanoscale, 2014;6(9):4538-43. (Royal Society of Chemistry -; Nanoscale -

The news editors report that additional information may be obtained by contacting N.T. Emerson, Dept. of Chemistry, Princeton University, Princeton, NJ 08544, United States. Additional authors for this research include C.H. Hsia, I.U. Rafalska-Metcalf and H. Yang (see also Intracellular Space).

Keywords for this news article include: Princeton, Cytoplasm, New Jersey, Nanoparticle, United States, Nanotechnology, Intracellular Space, Emerging Technologies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Life Science Weekly

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