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New Findings in Biosensing Described from Yeshiva University (A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly)

July 2, 2014

By a News Reporter-Staff News Editor at Biotech Week -- New research on Biosensing is the subject of a report. According to news reporting originating from Bronx, New York, by NewsRx correspondents, research stated, "Rho family GTPases control cell migration and participate in the regulation of cancer metastasis. Invadopodia, associated with invasive tumour cells, are crucial for cellular invasion and metastasis."

Our news editors obtained a quote from the research from Yeshiva University, "To study Rac1 GTPase in invadopodia dynamics, we developed a genetically encoded, single-chain Rac1 fluorescence resonance energy (FRET) transfer biosensor. The biosensor shows Rac1 activity exclusion from the core of invadopodia, and higher activity when invadopodia disappear, suggesting that reduced Rac1 activity is necessary for their stability, and Rac1 activation is involved in disassembly. Photoactivating Rac1 at invadopodia confirmed this previously unknown Rac1 function. We describe here an invadopodia disassembly model, where a signalling axis involving TrioGEF, Rac1, Pak1, and phosphorylation of cortactin, causes invadopodia dissolution."

According to the news editors, the research concluded: "This mechanism is critical for the proper turnover of invasive structures during tumour cell invasion, where a balance of proteolytic activity and locomotory protrusions must be carefully coordinated to achieve a maximally invasive phenotype."

For more information on this research see: A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nature Cell Biology, 2014;16(6):571-583,167-168. Nature Cell Biology can be contacted at: Nature Publishing Group, Macmillan Building, 4 Crinan St, London N1 9XW, England. (Nature Publishing Group -; Nature Cell Biology -

The news editors report that additional information may be obtained by contacting Y. Moshfegh, Yeshiva University, Albert Einstein College of Medicine, Gruss Lipper Biophoton Center, Dept. of Anat & Struct Biol, Bronx, NY 10461, United States. Additional authors for this research include J.J. Bravo-Cordero, V. Miskolci, J. Condeelis and L. Hodgson (see also Biosensing).

Keywords for this news article include: Bronx, New York, Biosensing, United States, Bioengineering, Bionanotechnology, Nanobiotechnology, North and Central America

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Source: Biotech Week

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