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New Findings in Adrenal Cortex Hormones Described from University of Illinois (Localization and Dynamics of Glucocorticoid Receptor at the Plasma...

July 4, 2014



New Findings in Adrenal Cortex Hormones Described from University of Illinois (Localization and Dynamics of Glucocorticoid Receptor at the Plasma Membrane of Activated Mast Cells)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Current study results on Adrenal Cortex Hormones have been published. According to news reporting originating in Urbana, Illinois, by NewsRx journalists, research stated, "In addition to their actions in the cell nucleus, glucocorticoids exhibit rapid non-nuclear responses that are mechanistically not well understood. To explain these effects, the localization of a glucocorticoid receptor (GR) expressed in mast cells as a GFP fusion was analyzed after activation of the cells on allergenic lipid arrays."

The news reporters obtained a quote from the research from the University of Illinois, "These arrays were produced on glass slides by dip-pen nanolithography (DPN) and total internal reflection (TIRF) microscopy was used to visualize the GR. A rapid glucocorticoid-independent and -dependent recruitment of the GR-GFP to the plasma cell membrane was observed following contact of the cells with the allergenic array. In addition, the mobility of the GR at the membrane was monitored by fluorescence recovery after photobleaching (FRAP) and shown to follow binding kinetics demonstrating interactions of the receptor with membrane-bound factors. Furthermore the recruitment of the GR to the cell membrane was shown to result in a glucocorticoid-mediated increase in Erk phosphorylation. This is evidenced by findings that destruction of the membrane composition of the mast cells by cholesterol depletion impairs the membrane localization of the GR and subsequent glucocorticoid-mediated enhancement of Erk phosphorylation."

According to the news reporters, the research concluded: "These results demonstrate a membrane localization and function of the GR in mast cell signaling."

For more information on this research see: Localization and Dynamics of Glucocorticoid Receptor at the Plasma Membrane of Activated Mast Cells. Small, 2014;10(10):1991-1998. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)

Our news correspondents report that additional information may be obtained by contacting E. Oppong, University of Illinois, Dept. of Phys, Urbana, IL 61801, United States. Additional authors for this research include P.N. Hedde, S. Sekula-Neuner, L.X. Yang, F. Brinkmann, R.M. Dorlich, M. Hirtz, H. Fuchs, G.U. Nienhaus and A.C.B. Cato (see also Adrenal Cortex Hormones).

Keywords for this news article include: Urbana, Illinois, Mast Cells, United States, Immune System, Glucocorticoids, Adrenal Cortex Hormones, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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