News Column

New Findings from University of Florida Update Understanding of Capsid (Tunable Protease-Activatable Virus Nanonodes)

July 3, 2014

By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Fresh data on Capsid are presented in a new report. According to news originating from Gainesville, Florida, by NewsRx correspondents, research stated, "We explored the unique signal integration properties of the self-assembling 60-mer protein capsid of adeno-associated virus (AAV), a clinically proven human gene therapy vector, by engineering proteolytic regulation of virus-receptor interactions such that processing of the capsid by proteases is required for infection."

Our news journalists obtained a quote from the research from the University of Florida, "We find the transfer function of our engineered protease-activatable viruses (PAVs), relating the degree of proteolysis (input) to PAV activity (output), is highly nonlinear, likely due to increased polyvalency. By exploiting this dynamic polyvalency, in combination with the self-assembly properties of the virus capsid, we show that mosaic PAVs can be constructed that operate under a digital AND gate regime, where two different protease inputs are required for virus activation."

According to the news editors, the research concluded: "These results show viruses can be engineered as signal-integrating nanoscale nodes whose functional properties are regulated by multiple proteolytic signals with easily tunable and predictable response surfaces, a promising development toward advanced control of gene delivery."

For more information on this research see: Tunable Protease-Activatable Virus Nanonodes. ACS Nano, 2014;8(5):4740-4746. ACS Nano can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society -; ACS Nano -

The news correspondents report that additional information may be obtained from J. Judd, University of Florida, Dept. of Biochem & Mol Biol, Gainesville, FL 32611, United States. Additional authors for this research include M.L. Ho, A. Tiwari, E.J. Gomez, C. Dempsey, K. Van Vliet, O.A. Igoshin, J.J. Silberg, M. Agbandje-McKenna and J. Suh (see also Capsid).

Keywords for this news article include: Virion, Florida, Protease, Gainesville, Engineering, Nucleocapsid, United States, Enzymes and Coenzymes, North and Central America

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Source: Gene Therapy Weekly

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