News Column

New Findings from Sichuan Agricultural University Update Understanding of DNA Vaccines (Immune response induced by candidate Sarcoptes scabiei var....

July 4, 2014



New Findings from Sichuan Agricultural University Update Understanding of DNA Vaccines (Immune response induced by candidate Sarcoptes scabiei var. cuniculi DNA vaccine encoding paramyosin in mice)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Data detailed on Biotechnology have been presented. According to news reporting from Ya'an, People's Republic of China, by NewsRx journalists, research stated, "Sarcoptes scabiei is the causal agent of the highly contagious disease sarcoptic mange (scabies) that affects animals and humans worldwide. An increasing number of cases of treatment failure is being reported because of drug resistance."

The news correspondents obtained a quote from the research from Sichuan Agricultural University, "The development of a specific vaccine would be a sustainable option for control of this disease. In this study, we cloned and expressed a S. scabiei gene encoding paramyosin (PAR) and investigated the immune response elicited by DNA encoding PAR in mice. The ability of the DNA vaccine to express antigen in COS-7 cells was confirmed by RT-PCR and IFA. The immune response induced by DNA vaccine was investigated by ELISA, splenocyte proliferation assay, and cytokine production assay. Compared to the pVAX1 control group, the PAR DNA vaccination group showed the higher levels of IgG, IgG1, IgG2a, IgE, IgM, stronger lymphocyte proliferation in mouse spleen, and larger production of IL-2, IL-4, IL-5, and IFN-gamma in the supernatant of cultures from splenocytes. These results indicated that the PAR DNA vaccine induced a mixed Th1/Th2 response in mice."

According to the news reporters, the research concluded: "Our results revealed that the S. scabiei PAR DNA vaccine induced both a humoral and cellular immune response, which would provide basic data for the further study to develop an effective vaccine against sarcoptic mange."

For more information on this research see: Immune response induced by candidate Sarcoptes scabiei var. cuniculi DNA vaccine encoding paramyosin in mice. Experimental and Applied Acarology, 2014;63(3):401-412. Experimental and Applied Acarology can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Experimental and Applied Acarology - www.springerlink.com/content/0168-8162/)

Our news journalists report that additional information may be obtained by contacting X.B. Gu, Sichuan Agricultural University, Coll Anim Sci & Technol, Yaan 625014, People's Republic of China. Additional authors for this research include Y. Xie, S.X. Wang, X.R. Peng, S.J. Lai and G.Y. Yang (see also Biotechnology).

Keywords for this news article include: Asia, Biotechnology, Ya'an, DNA Research, DNA Vaccines, Synthetic Vaccines, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Health & Medicine Week


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters