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New Findings from Aristotle University Describe Advances in Mononuclear Leukocytes (Potentiation by caffeine of cytogenetic damage induced by...

July 4, 2014



New Findings from Aristotle University Describe Advances in Mononuclear Leukocytes (Potentiation by caffeine of cytogenetic damage induced by steroidal derivatives in human lymphocytes in vitro)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Mononuclear Leukocytes. According to news originating from Thessaloniki, Greece, by NewsRx correspondents, research stated, "We studied the effects of three newly synthesized steroidal derivatives of nitrogen mustards, alone or in combination with caffeine, on sister chromatid exchange (SCE) frequencies and on human lymphocyte proliferation kinetics. The agents have as alkylator functionalities either P-N,N-bis(2-chloroethyl)aminophenyl-buturate (CHL) or P-N,N-bis(2-chloroethyl)aminophenyl-acetate (PHE), esterified with a modified steroidal nucleus."

Our news journalists obtained a quote from the research from Aristotle University, "An enhancement of SCE frequency was seen with compounds which contain either PHE or CHL as alkylators and are esterified with a steroidal nucleus having added a cholestene group in the 17-position of the D-ring. The exocyclic insertion of an -NHCO- group in the D-ring of the steroidal nucleus esterified with PHE (amide ester of PHE) gave a compound showing increased SCE frequency. Enhanced cytogenetic damage was observed when lymphocytes were exposed in vitro to caffeine."

According to the news editors, the research concluded: "The compounds, alone or in combination with caffeine, caused a concentration-dependent increase in SCE frequencies and cell division delays, and caffeine was found to act synergistically with the steroidal alkylators."

For more information on this research see: Potentiation by caffeine of cytogenetic damage induced by steroidal derivatives in human lymphocytes in vitro. Mutation Research-Genetic Toxicology and Environmental Mutagenesis, 2014;766():42-45. Mutation Research-Genetic Toxicology and Environmental Mutagenesis can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands (see also Mononuclear Leukocytes).

The news correspondents report that additional information may be obtained from C. Mourelatos, Aristotle University, Fac Med, Lab Biol & Genet, Thessaloniki, Greece. Additional authors for this research include S. Nikolaropoulos, M. Fousteris, G. Pairas, M. Argyraki, D. Lykidis, S. Fidani, D. Mourelatos and T. Lialiaris.

Keywords for this news article include: Greece, Europe, Immunology, Blood Cells, Lymphocytes, Thessaloniki, Mononuclear Leukocytes, Hemic and Immune Systems

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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