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Investigators at University of Minnesota Have Reported New Data on Biochemistry (Microfluidics-based in vivo mimetic systems for the study of...

July 2, 2014



Investigators at University of Minnesota Have Reported New Data on Biochemistry (Microfluidics-based in vivo mimetic systems for the study of cellular biology)

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Biochemistry have been presented. According to news reporting from Minneapolis, Minnesota, by NewsRx journalists, research stated, "The human body is a complex network of molecules, organelles, cells, tissues, and organs: an uncountable number of interactions and transformations interconnect all the system's components. In addition to these biochemical components, biophysical components, such as pressure, flow, and morphology, and the location of all of these interactions play an important role in the human body."

The news correspondents obtained a quote from the research from the University of Minnesota, "Technical difficulties have frequently limited researchers from observing cellular biology as it occurs within the human body, but some state-of-the-art analytical techniques have revealed distinct cellular behaviors that occur only in the context of the interactions. These types of findings have inspired bioanalytical chemists to provide new tools to better understand these cellular behaviors and interactions. What blocks us from understanding critical biological interactions in the human body? Conventional approaches are often too naive to provide realistic data and in vivo whole animal studies give complex results that may or may not be relevant for humans. Microfluidics offers an opportunity to bridge these two extremes: while these studies will not model the complexity of the in vivo human system, they can control the complexity so researchers can examine critical factors of interest carefully and quantitatively. In addition, the use of human cells, such as cells isolated from donated blood, captures human-relevant data and limits the use of animals in research. In addition, researchers can adapt these systems easily and cost-effectively to a variety of high-end signal transduction mechanisms, facilitating high-throughput studies that are also spatially, temporally, or chemically resolved. These strengths should allow microfluidic platforms to reveal critical parameters in the human body and provide insights that will help with the translation of pharmacological advances to clinical trials. In this Account, we describe selected microfluidic innovations within the last 5 years that focus on modeling both biophysical and biochemical interactions in cellular communication, such as flow and cell-cell networks. We also describe more advanced systems that mimic higher level biological networks, such as organ on-a-chip and animal on-a-chip models. Since the first papers in the early 1990s, interest in the bioanalytical use of microfluidics has grown significantly. Advances in micro-/nanofabrication technology have allowed researchers to produce miniaturized, biocompatible assay platforms suitable for microfluidic studies in biochemistry and chemical biology. Well-designed microfluidic platforms can achieve quick, in vitro analyses on pico-and femtoliter volume samples that are temporally, spatially, and chemically resolved. In addition, controlled cell culture techniques using a microfluidic platform have produced biomimetic systems that allow researchers to replicate and monitor physiological interactions. Pioneering work has successfully created cell-fluid, cell-cell, cell-tissue, tissue-tissue, even organ-like level interfaces."

According to the news reporters, the research concluded: "Researchers have monitored cellular behaviors in these biomimetic microfluidic environments, producing validated model systems to understand human pathophysiology and to support the development of new therapeutics."

For more information on this research see: Microfluidics-based in vivo mimetic systems for the study of cellular biology. Accounts of Chemical Research, 2014;47(4):1165-73. (American Chemical Society - www.acs.org; Accounts of Chemical Research - www.pubs.acs.org/journal/achre4)

Our news journalists report that additional information may be obtained by contacting D. Kim, Dept. of Chemistry, University of Minnesota , 207 Pleasant Street Southeast, Minneapolis, Minnesota 55455, United States. Additional authors for this research include X. Wu, A.T. Young and C.L Haynes (see also Biochemistry).

Keywords for this news article include: Minnesota, Minneapolis, Biochemical, Biomimetics, Biochemistry, United States, Bioengineering, Bionanotechnology, Nanobiotechnology, Emerging Technologies, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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